Aversive taste stimuli increase CGRP levels in the gustatory insular cortex of the rat

Takashi Yamamoto, Ryuji Matsuo, Hiroyuki Ichikawa, Satoshi Wakisaka, Michio Akai, Yasuo Imai, Norifumi Yonehara, Reizo Inoki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Calcitonin gene-related peptide-like immunoreactivity (CGRP-IR) was surveyed immunohistochemically in the insular cortex of the rat, and the levels of insular cortical CGRP-IR were measured with the radioimmunoassay method following intraoral stimulation with various taste stimuli. CGRP-IR was localized in nerve fibers within the agranular and dysgranular insular cortices. The CGRP-IR levels in the rostral (gustatory) part of the insular cortex were increased significantly by strongly aversive taste stimuli such as quinine hydrochloride and conditioned taste stimuli (NaCl and sucrose) which animals had been taught to avoid. The results suggest that CGRP in the gustatory insular cortex is concerned with rejection or avoidance behaviors to aversive taste stimuli.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalNeuroscience Letters
Issue number2-3
Publication statusPublished - 1990 May 4
Externally publishedYes


  • Calcitonin gene-related peptide
  • Immunohistochemistry
  • Insular cortex
  • Radioimmunoassay
  • Taste

ASJC Scopus subject areas

  • Neuroscience(all)


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