B-raf, a new member of the raf family, is activated by DNA rearrangement.

S. Ikawa; M. Fukui; Y. Ueyama; N. Tamaoki; T. Yamamoto; K. Toyoshima

doi:10.1128/MCB.8.6.2651

B-raf, a new member of the raf family, is activated by DNA rearrangement.

S. Ikawa, M. Fukui, Y. Ueyama, N. Tamaoki, T. Yamamoto, K. Toyoshima

Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Abstract

Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

Original language	English
Pages (from-to)	2651-2654
Number of pages	4
Journal	Molecular and cellular biology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1128/MCB.8.6.2651
Publication status	Published - 1988 Jun
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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title = "B-raf, a new member of the raf family, is activated by DNA rearrangement.",

abstract = "Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.",

author = "S. Ikawa and M. Fukui and Y. Ueyama and N. Tamaoki and T. Yamamoto and K. Toyoshima",

year = "1988",

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AU - Fukui, M.

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AU - Tamaoki, N.

AU - Yamamoto, T.

AU - Toyoshima, K.

PY - 1988/6

Y1 - 1988/6

N2 - Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

AB - Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

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B-raf, a new member of the raf family, is activated by DNA rearrangement.

Abstract

ASJC Scopus subject areas

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