TY - JOUR
T1 - Basal cell carcinoma with spontaneous regression
T2 - A case report and immunohistochemical study
AU - Fujimura, Taku
AU - Kakizaki, Aya
AU - Kambayashi, Yumi
AU - Aiba, Setsuya
PY - 2012/5
Y1 - 2012/5
N2 - Spontaneous regression of basal cell carcinoma (BCC) is rare, and characterized by various tumor-infiltrating lymphocytes (TILs) in the tumor. A previous report suggested that these infiltrated lymphocytes consist of type 1 helper T cells, but no detailed phenotypical analysis of other TILs has been demonstrated yet. In this report, we describe an 84-year-old Japanese patient with spontaneous regression of BCC. In the present case, we investigated the immunohistochemical profiles of TILs, not only focusing on the cytotoxic T cells, but the profiles of immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study sheds light on the immunological mechanisms of tumor rejection in human BCC.
AB - Spontaneous regression of basal cell carcinoma (BCC) is rare, and characterized by various tumor-infiltrating lymphocytes (TILs) in the tumor. A previous report suggested that these infiltrated lymphocytes consist of type 1 helper T cells, but no detailed phenotypical analysis of other TILs has been demonstrated yet. In this report, we describe an 84-year-old Japanese patient with spontaneous regression of BCC. In the present case, we investigated the immunohistochemical profiles of TILs, not only focusing on the cytotoxic T cells, but the profiles of immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study sheds light on the immunological mechanisms of tumor rejection in human BCC.
KW - Basal cell carcinoma
KW - Spontaneous regression
KW - Tumor-infiltrating lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=84866661828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866661828&partnerID=8YFLogxK
U2 - 10.1159/000339621
DO - 10.1159/000339621
M3 - Article
AN - SCOPUS:84866661828
SN - 1662-6567
VL - 4
SP - 125
EP - 132
JO - Case Reports in Dermatology
JF - Case Reports in Dermatology
IS - 2
ER -