Basic and clinical studies on ApoE gene typing by line probe assay (LiPA) as a biological marker for Alzheimer's disease and related disorders: Multicenter study in Japan

T. Nishimura; M. Takeda; K. Shinosaki; T. Nishikawa; Y. Nakamura; Y. Yoshida; H. Sasaki; H. Arai; S. Hirai; M. Shouji; K. Isse; K. Tanaka; M. Hamamoto; H. Yamamoto; T. Matsubayashi; K. Nakashima; K. Urakami; Y. Adachi; S. Nakamura; H. Toji; H. Yoshida

Basic and clinical studies on ApoE gene typing by line probe assay (LiPA) as a biological marker for Alzheimer's disease and related disorders: Multicenter study in Japan

T. Nishimura, M. Takeda, K. Shinosaki, T. Nishikawa, Y. Nakamura, Y. Yoshida, H. Sasaki, H. Arai, S. Hirai, M. Shouji, K. Isse, K. Tanaka, M. Hamamoto, H. Yamamoto, T. Matsubayashi, K. Nakashima, K. Urakami, Y. Adachi, S. Nakamura, H. TojiH. Yoshida

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The fundamental reagent capability and clinical significance of ApoE gene typing has been investigated. The result of each test shows that the reagent capability satisfied the expected standard. Four-hundred thirty-nine samples classified into three groups (Alzheimer's disease (AD), other types of dementia and nondementia) were measured to examine the clinical significance. The rate of ε4 genotype of each group was 31.5%, 14.6%, 10.4%, respectively. The AD group had a higher rate than the other groups (p < 0.001). The measurement of ApoE genotype is suggested to be useful as one of the guidelines in the diagnosis of AD.

Original language	English
Pages (from-to)	793-799
Number of pages	7
Journal	Methods and Findings in Experimental and Clinical Pharmacology
Volume	20
Issue number	9
Publication status	Published - 1998
Externally published	Yes

Keywords

Alzheimer's disease
ApoE genotype
ApoE4
Dementia
LiPA

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

Cite this

Nishimura, T., Takeda, M., Shinosaki, K., Nishikawa, T., Nakamura, Y., Yoshida, Y., Sasaki, H., Arai, H., Hirai, S., Shouji, M., Isse, K., Tanaka, K., Hamamoto, M., Yamamoto, H., Matsubayashi, T., Nakashima, K., Urakami, K., Adachi, Y., Nakamura, S., ... Yoshida, H. (1998). Basic and clinical studies on ApoE gene typing by line probe assay (LiPA) as a biological marker for Alzheimer's disease and related disorders: Multicenter study in Japan. Methods and Findings in Experimental and Clinical Pharmacology, 20(9), 793-799.

Basic and clinical studies on ApoE gene typing by line probe assay (LiPA) as a biological marker for Alzheimer's disease and related disorders: Multicenter study in Japan. / Nishimura, T.; Takeda, M.; Shinosaki, K. et al.
In: Methods and Findings in Experimental and Clinical Pharmacology, Vol. 20, No. 9, 1998, p. 793-799.

Research output: Contribution to journal › Article › peer-review

Nishimura, T, Takeda, M, Shinosaki, K, Nishikawa, T, Nakamura, Y, Yoshida, Y, Sasaki, H, Arai, H, Hirai, S, Shouji, M, Isse, K, Tanaka, K, Hamamoto, M, Yamamoto, H, Matsubayashi, T, Nakashima, K, Urakami, K, Adachi, Y, Nakamura, S, Toji, H & Yoshida, H 1998, 'Basic and clinical studies on ApoE gene typing by line probe assay (LiPA) as a biological marker for Alzheimer's disease and related disorders: Multicenter study in Japan', Methods and Findings in Experimental and Clinical Pharmacology, vol. 20, no. 9, pp. 793-799.

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abstract = "The fundamental reagent capability and clinical significance of ApoE gene typing has been investigated. The result of each test shows that the reagent capability satisfied the expected standard. Four-hundred thirty-nine samples classified into three groups (Alzheimer's disease (AD), other types of dementia and nondementia) were measured to examine the clinical significance. The rate of ε4 genotype of each group was 31.5%, 14.6%, 10.4%, respectively. The AD group had a higher rate than the other groups (p < 0.001). The measurement of ApoE genotype is suggested to be useful as one of the guidelines in the diagnosis of AD.",

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AU - Shouji, M.

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AU - Yamamoto, H.

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AU - Nakashima, K.

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AU - Nakamura, S.

AU - Toji, H.

AU - Yoshida, H.

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Basic and clinical studies on ApoE gene typing by line probe assay (LiPA) as a biological marker for Alzheimer's disease and related disorders: Multicenter study in Japan

Abstract

Keywords

ASJC Scopus subject areas

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