Basis of anti-angiogenic therapy

Research output: Contribution to journalArticlepeer-review


Angiogenesis is a process by which new blood vessels are formed from pre-existing ones. It is regulated by the balance between angiogenic factors and angiogenesis inhibitors. Angiogenesis is considered to be essential for the growth of various solid tumors. Therefore, the inhibition of tumor angiogenesis has become a new strategy for the treatment of malignant tumors. This review describes the recent understanding of the mechanism of angiogenesis, the factors involved in angiogenesis, and the anti-angiogenic drugs in current clinical trials.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
Issue number2
Publication statusPublished - 1999


  • Angiogenesis inhibitor
  • Angiogenic factor
  • Anti- angiogenic therapy
  • Tumor angiogenesis


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