TY - JOUR
T1 - Bioactive TiNbSn alloy prepared by anodization in sulfuric acid electrolytes
AU - Masahashi, N.
AU - Mori, Y.
AU - Tanaka, H.
AU - Kogure, A.
AU - Inoue, H.
AU - Ohmura, K.
AU - Kodama, Y.
AU - Nishijima, M.
AU - Itoi, E.
AU - Hanada, S.
N1 - Funding Information:
The authors wish to acknowledge Mr. I. Nagano and Ms. Y. Matsuda for sample preparations, and Mr. I Narita for EPMA experiments. A part of this work was supported by the Center for Integrated Nano Technology Support (CINTS), Tohoku University , as a program of “Nanotechnology Platform” of the Ministry of Education, Culture, Sports and Technology ( MEXT ), Japan, and a cooperative program of the Cooperative Research and Development Center for Advanced Materials, IMR, Tohoku University . This study was carried out using research resources by the Development of Medical Devices through Collaboration between Medicine and Industry from Japan Agency for Medical Research and Development, AMED, and by Japan Society for the Promotion of Science (No. 15H04138 to Naoya Masahashi and No. 15 K10428 to Yu Mori).
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/5
Y1 - 2019/5
N2 - The bioactivity of anodized near-β TiNbSn alloy with low Young's modulus prepared in sulfuric acid electrolytes was examined to explore the osseointegration mechanism with a focus on the role of anodic oxide. Hydroxyapatite (HA) precipitated on the surface of anodic oxide following immersion in Hank's solution, and precipitation accelerated with increase in the sulfuric acid concentration of the electrolyte. HA is formed on the surface of as-anodized oxide without subsequent annealing or hot water (HW) treatment. This outcome differs from that of a previous study using anodized TiNbSn alloy prepared in acetic acid electrolytes requiring for subsequent HW treatment. It was found that the oxide anodized in sulfuric acid electrolyte contains a large amount of internal pores and is highly crystallized thick TiO 2 , whereas the same prepared in the acetic acid electrolyte is low crystalline thin TiO 2 containing a small amount of pores. The present anodized TiNbSn alloy is preferred for maintaining the low Young's modulus of the alloy and eliminating the subsequent treatment to increase the Young's modulus. A model to rationalize the bioactivity of the present anodic oxide is proposed based on the series of studies. It is concluded that the sulfuric acid electrolyte is favorable for both HA formation and low Young's modulus, and the bioactivity is attributed to the anodic TiO 2 that facilitates incorporation of bone ingredients.
AB - The bioactivity of anodized near-β TiNbSn alloy with low Young's modulus prepared in sulfuric acid electrolytes was examined to explore the osseointegration mechanism with a focus on the role of anodic oxide. Hydroxyapatite (HA) precipitated on the surface of anodic oxide following immersion in Hank's solution, and precipitation accelerated with increase in the sulfuric acid concentration of the electrolyte. HA is formed on the surface of as-anodized oxide without subsequent annealing or hot water (HW) treatment. This outcome differs from that of a previous study using anodized TiNbSn alloy prepared in acetic acid electrolytes requiring for subsequent HW treatment. It was found that the oxide anodized in sulfuric acid electrolyte contains a large amount of internal pores and is highly crystallized thick TiO 2 , whereas the same prepared in the acetic acid electrolyte is low crystalline thin TiO 2 containing a small amount of pores. The present anodized TiNbSn alloy is preferred for maintaining the low Young's modulus of the alloy and eliminating the subsequent treatment to increase the Young's modulus. A model to rationalize the bioactivity of the present anodic oxide is proposed based on the series of studies. It is concluded that the sulfuric acid electrolyte is favorable for both HA formation and low Young's modulus, and the bioactivity is attributed to the anodic TiO 2 that facilitates incorporation of bone ingredients.
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U2 - 10.1016/j.msec.2019.01.033
DO - 10.1016/j.msec.2019.01.033
M3 - Article
C2 - 30813081
AN - SCOPUS:85059902410
SN - 0928-4931
VL - 98
SP - 753
EP - 763
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -