TY - JOUR
T1 - Biocompatible composite of cellulose nanocrystal and hydroxyapatite with large mechanical strength
AU - Sato, Ryota
AU - Arita, Toshihiko
AU - Shimada, Ryuichiro
AU - Nohara, Tomohiro
AU - Tabata, Keisuke
AU - Koseki, Kazuki
AU - Umemoto, Kazuki
AU - Masuhara, Akito
N1 - Funding Information:
This work was supported by the cooperative research program of “Network Joint Research Center for Materials and Devices” and JSPS KAKENHI No. JP18H01717.
Publisher Copyright:
© 2020, Springer Nature B.V.
PY - 2021/1
Y1 - 2021/1
N2 - Exploring the simple fabrication process to prepare CNC@HAp for biological tissues is still a challenging subject considering the wide applications of the composites for bio tissues. In this work, aiming for the fabrication of CNC@HAp composites via a simple and environment-friendly process and materials, we propose the neutralization titration in the presence of CNCs in the suspension. Core–shell structured composite of cellulose nanocrystal (CNC) and hydroxyapatite (HAp) (CNC@HAp) was successfully synthesized via simple aqueous neutralization titration. The method studied successfully hybridizes CNCs with a certain amount of HAps and easily controls the coating amounts of HAps from 9 wt% to 17 wt%. In particular, CNC@HAp pellets were easily prepared by simple compression molding from the powder of hybridized CNCs and HAps and the pellets showed high mechanical strength of over 500 N with a low strain of less than 5%. Both the process and the product of the study were environmental-friendly, no toxicity, simple and pure therefore the CNC@HAp can be easily applied to tissue engineering and medical purposes. Graphic abstract: [Figure not available: see fulltext.]
AB - Exploring the simple fabrication process to prepare CNC@HAp for biological tissues is still a challenging subject considering the wide applications of the composites for bio tissues. In this work, aiming for the fabrication of CNC@HAp composites via a simple and environment-friendly process and materials, we propose the neutralization titration in the presence of CNCs in the suspension. Core–shell structured composite of cellulose nanocrystal (CNC) and hydroxyapatite (HAp) (CNC@HAp) was successfully synthesized via simple aqueous neutralization titration. The method studied successfully hybridizes CNCs with a certain amount of HAps and easily controls the coating amounts of HAps from 9 wt% to 17 wt%. In particular, CNC@HAp pellets were easily prepared by simple compression molding from the powder of hybridized CNCs and HAps and the pellets showed high mechanical strength of over 500 N with a low strain of less than 5%. Both the process and the product of the study were environmental-friendly, no toxicity, simple and pure therefore the CNC@HAp can be easily applied to tissue engineering and medical purposes. Graphic abstract: [Figure not available: see fulltext.]
KW - Biomedical materials
KW - Cellulose nanocrystal
KW - Dental materials
KW - Hydroxyapatite
KW - Sustainable development goals (SDGs)
KW - Tissue engineering materials
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U2 - 10.1007/s10570-020-03550-7
DO - 10.1007/s10570-020-03550-7
M3 - Article
AN - SCOPUS:85095942996
SN - 0969-0239
VL - 28
SP - 871
EP - 879
JO - Cellulose
JF - Cellulose
IS - 2
ER -