@article{fe60ed2374a34cca8de701ed5ae1e36e,
title = "Bioinspired Total Synthesis of Delitschiapyrone A",
abstract = "A bioinspired seven-step total synthesis of delitschiapyrone A was accomplished in 32% overall yield from commercially available 4-bromo-3,5-dimethoxybenzoic acid. The key step of the synthesis is an exclusively regioselective and diastereoselective reaction cascade consisting of the Diels-Alder reaction, α-ketol rearrangement, and cyclic hemiacetalization, achieved by simply stirring a heterogeneous mixture of two Diels-Alder substrates (putative biosynthetic intermediates) and water at 35 °C, directly furnishing the pentacyclic natural product in 75% yield.",
author = "Kazuki Kurasawa and Eunsang Kwon and Shigefumi Kuwahara and Masaru Enomoto",
note = "Funding Information: This work was financially supported by JSPS KAKENHI (Grant No. 16K07708), by JSPS Core-to-Core Program, A: Advanced Research Networks entitled “Establishment of International Agricultural Immunology Research-Core for a Quantum Improvement in Food Safety”, and by the Platform Project for Supporting Drug Discovery and Life Science Research funded by the Japan Agency for Medical Research and Development (AMED). We thank Ms. Yuka Taguchi (Tohoku University) for her help with NMR and MS measurements. Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = aug,
day = "3",
doi = "10.1021/acs.orglett.8b01932",
language = "English",
volume = "20",
pages = "4645--4648",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "15",
}