TY - JOUR
T1 - Biological evaluation of 5-Methyl-branched-chain ω-[18F]fluorofatty acid
T2 - A potential myocardial imaging tracer for positron emission tomography
AU - Takahashi, Toshihiro
AU - Nishimura, Shin Ichi
AU - Ido, Tatsuo
AU - Ishiwata, Ki Ichi
AU - Iwata, Ren
N1 - Funding Information:
Operation of the cyclotron by members of the Cyclotron and Radioisotope Center is acknowledged and appreciated. Part of this study was presented at the 7th International Symposium on Radiopharmaceutical Chemistry, Groningen, The Netherlands, 1988, and the 37th Annual Society of Nuclear Medicine Meeting, Washington DC, 1990. This work was supported in part by a grant-in-aid for scientific research, Ministry of Education, Japan.
PY - 1996/4
Y1 - 1996/4
N2 - 5-Methyl-17-[18F]fIuoroheptadecanoic acid (5-MFHA) has been proposed as a new myocardial imaging tracer for positron emission tomography (PET), containing methyl-branching at the odd-numbered position, except the 3-position. To compare the site of methyl-branching of fatty acids on the contribution to myocardial imaging, the biological evaluation of 5-MFHA - using accumulation studies, metabolic studies, and PET studies of the heart muscle - was investigated. In the comparative biodistribution studies for 16-[18F]fluoropalmitic acid (FPA), 3-methyl-17-[18F]fluoroheptadecanoic acid (3-MFHA) and 5-MFHA, the initial myocardial uptake of 5-MFHA (2.64 [% dose/g tissue]) was relatively high between those of FPA and 3-MFHA (3.45 and 1.58, respectively), and the washout from myocardium of 5-MFHA was midway between those of FPA and 3-MFHA. In the lipid analysis studies, 5-MFHA was mainly metabolized to triglycerides in the myocardium, and its metabolic pattern was similar to that of straight-chain fatty acids (FPA). In the PET studies using 5-MFHA in canines, good myocardial images were obtained for up to 30 min after injection.
AB - 5-Methyl-17-[18F]fIuoroheptadecanoic acid (5-MFHA) has been proposed as a new myocardial imaging tracer for positron emission tomography (PET), containing methyl-branching at the odd-numbered position, except the 3-position. To compare the site of methyl-branching of fatty acids on the contribution to myocardial imaging, the biological evaluation of 5-MFHA - using accumulation studies, metabolic studies, and PET studies of the heart muscle - was investigated. In the comparative biodistribution studies for 16-[18F]fluoropalmitic acid (FPA), 3-methyl-17-[18F]fluoroheptadecanoic acid (3-MFHA) and 5-MFHA, the initial myocardial uptake of 5-MFHA (2.64 [% dose/g tissue]) was relatively high between those of FPA and 3-MFHA (3.45 and 1.58, respectively), and the washout from myocardium of 5-MFHA was midway between those of FPA and 3-MFHA. In the lipid analysis studies, 5-MFHA was mainly metabolized to triglycerides in the myocardium, and its metabolic pattern was similar to that of straight-chain fatty acids (FPA). In the PET studies using 5-MFHA in canines, good myocardial images were obtained for up to 30 min after injection.
KW - 5-Methyl-17-[F]fluoroheptadecanoic acid
KW - Labeled fatty acids
KW - Methyl branching
KW - Myocardial imaging
KW - Positron emission tomography
KW - β-oxidation
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U2 - 10.1016/0969-8051(95)02084-5
DO - 10.1016/0969-8051(95)02084-5
M3 - Article
C2 - 8782241
AN - SCOPUS:0029970094
SN - 0969-8051
VL - 23
SP - 303
EP - 308
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
IS - 3
ER -
