Biologics modulate antinuclear antibodies, immunoglobulin E, and eosinophil counts in psoriasis patients

Riichiro Sugiura, Hitoshi Terui, Ryoko Shimada-Omori, Emi Yamazaki, Kenichiro Tsuchiyama, Toshiya Takahashi, Setsuya Aiba, Kenshi Yamasaki

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Psoriasis is a chronic disease centered on tumor necrosis factor (TNF), interleukin (IL)-23, and IL-17 axis. While psoriasis patients benefit from biologics targeting TNF, IL-17s, and IL-23 nowadays, suppression of these molecules could modulate the balances of immune systems. However, the incidence of autoimmune disease and T-helper 2 reaction during biologic treatments for psoriasis patients is not well documented. We retrospectively examined antinuclear antibody (ANA), eosinophil counts, and immunoglobulin E (IgE) levels for psoriasis patients who underwent biologic treatments in our dermatology clinic from June 10, 2010 to January 29, 2020. A cumulative total of 199 biologic treatments were performed for a total of 128 psoriasis patients. Compared to the non-biologic group of 109 psoriasis patients who received non-biologic treatment, patients treated with infliximab showed more incidents of high ANA (14%, p = 0.039) and high eosinophils (14%, p = 0.021). The use of brodalumab increased incidents of high eosinophils (21%, p = 0.005) but did not affect increase in ANA and IgE. The increase in high IgE level was observed significantly more during the use of risankizumab (15%, p = 0.011). Methotrexate was the most frequently used concomitant systemic treatment, but methotrexate did not affect ANA, eosinophil counts, and IgE levels. Since the biologics for psoriasis treatment modulate the balance of T-helper cells, careful observation is required to detect unexpected changes of systemic immune conditions under biologic treatments.

Original languageEnglish
Pages (from-to)1739-1744
Number of pages6
JournalJournal of Dermatology
Issue number11
Publication statusPublished - 2021 Nov


  • antinuclear antibody
  • biologics
  • eosinophil
  • immunoglobulin E
  • psoriasis


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