Biomimetic self-assembly of calcium phosphate templated by PNIPAAm nanogels for sustained smart drug delivery

Jun Shi; Wenyan Qi; Gefei Li; Shaokui Cao

doi:10.1016/j.msec.2012.04.008

Biomimetic self-assembly of calcium phosphate templated by PNIPAAm nanogels for sustained smart drug delivery

Jun Shi, Wenyan Qi, Gefei Li, Shaokui Cao

ENG - Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Poly(N-isopropylacrylamide) (PNIPAAm)/calcium phosphate (CaP) hybrid nanocomposites with dual-responsive controlled drug delivery property have been prepared by in-situ biomineralization process. Poly(acrylic acid) (PAA) is used as a crystal growth additive to control the morphology of the hybrid nanocomposites. The interaction between PAA and Ca ²⁺ contributes to the formation of homogeneous and robust nanocomposites. Vitamin B ₂ release behavior is found to be pH- and thermal-responsive. Additionally, the release profiles are sustained with the introduction of CaP, indicating that CaP nanocrystallines could decrease the permeation of the encapsulated drug effectively. The results suggest that the prepared hybrid nanocomposites can be used as smart nanoscale materials for sustained dual-responsive drug delivery.

Original language	English
Pages (from-to)	1299-1306
Number of pages	8
Journal	Materials Science and Engineering C
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/j.msec.2012.04.008
Publication status	Published - 2012 Jul 1

Keywords

Biomimetic
Nanocomposites
Self-assembly
Smart drug delivery
pH/temperature responsive

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.msec.2012.04.008

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title = "Biomimetic self-assembly of calcium phosphate templated by PNIPAAm nanogels for sustained smart drug delivery",

abstract = "Poly(N-isopropylacrylamide) (PNIPAAm)/calcium phosphate (CaP) hybrid nanocomposites with dual-responsive controlled drug delivery property have been prepared by in-situ biomineralization process. Poly(acrylic acid) (PAA) is used as a crystal growth additive to control the morphology of the hybrid nanocomposites. The interaction between PAA and Ca 2+ contributes to the formation of homogeneous and robust nanocomposites. Vitamin B 2 release behavior is found to be pH- and thermal-responsive. Additionally, the release profiles are sustained with the introduction of CaP, indicating that CaP nanocrystallines could decrease the permeation of the encapsulated drug effectively. The results suggest that the prepared hybrid nanocomposites can be used as smart nanoscale materials for sustained dual-responsive drug delivery.",

keywords = "Biomimetic, Nanocomposites, Self-assembly, Smart drug delivery, pH/temperature responsive",

author = "Jun Shi and Wenyan Qi and Gefei Li and Shaokui Cao",

note = "Funding Information: This work was financially supported by the National Natural Science Foundation of China (Project 20874090 ) and the Research Foundation of the Young Core Instructor of Henan Province, China (2009).",

year = "2012",

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doi = "10.1016/j.msec.2012.04.008",

language = "English",

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journal = "Materials Science and Engineering C",

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T1 - Biomimetic self-assembly of calcium phosphate templated by PNIPAAm nanogels for sustained smart drug delivery

AU - Shi, Jun

AU - Qi, Wenyan

AU - Li, Gefei

AU - Cao, Shaokui

N1 - Funding Information: This work was financially supported by the National Natural Science Foundation of China (Project 20874090 ) and the Research Foundation of the Young Core Instructor of Henan Province, China (2009).

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Poly(N-isopropylacrylamide) (PNIPAAm)/calcium phosphate (CaP) hybrid nanocomposites with dual-responsive controlled drug delivery property have been prepared by in-situ biomineralization process. Poly(acrylic acid) (PAA) is used as a crystal growth additive to control the morphology of the hybrid nanocomposites. The interaction between PAA and Ca 2+ contributes to the formation of homogeneous and robust nanocomposites. Vitamin B 2 release behavior is found to be pH- and thermal-responsive. Additionally, the release profiles are sustained with the introduction of CaP, indicating that CaP nanocrystallines could decrease the permeation of the encapsulated drug effectively. The results suggest that the prepared hybrid nanocomposites can be used as smart nanoscale materials for sustained dual-responsive drug delivery.

AB - Poly(N-isopropylacrylamide) (PNIPAAm)/calcium phosphate (CaP) hybrid nanocomposites with dual-responsive controlled drug delivery property have been prepared by in-situ biomineralization process. Poly(acrylic acid) (PAA) is used as a crystal growth additive to control the morphology of the hybrid nanocomposites. The interaction between PAA and Ca 2+ contributes to the formation of homogeneous and robust nanocomposites. Vitamin B 2 release behavior is found to be pH- and thermal-responsive. Additionally, the release profiles are sustained with the introduction of CaP, indicating that CaP nanocrystallines could decrease the permeation of the encapsulated drug effectively. The results suggest that the prepared hybrid nanocomposites can be used as smart nanoscale materials for sustained dual-responsive drug delivery.

KW - Biomimetic

KW - Nanocomposites

KW - Self-assembly

KW - Smart drug delivery

KW - pH/temperature responsive

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U2 - 10.1016/j.msec.2012.04.008

DO - 10.1016/j.msec.2012.04.008

M3 - Article

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SN - 0928-4931

VL - 32

SP - 1299

EP - 1306

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

IS - 5

ER -

Biomimetic self-assembly of calcium phosphate templated by PNIPAAm nanogels for sustained smart drug delivery

Abstract

Keywords

ASJC Scopus subject areas

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