The adhesion of bubbles underwater remains the greatest cause of malfunctions in applications such as microfluidics, medical devices and heat exchangers. There is therefore an emerging need for ultra-bubble-repellent surfaces. Inspired by fish scales, which show high bubble repellency due to their hydrophilic nature and surface microstructures, we propose a novel method for preparing ultra-bubble-repellent surfaces by the hydrophilic treatment of self-organized microstructures. When in contact with air bubbles underwater, the artificial hydrophilic microstructured surfaces had a higher contact angle and a lower adhesion force than a flat surface. The mechanism leading to these properties is also investigated. Our method for the fabrication of ultra-bubble-repellent, hydrophilic, microstructured surfaces is simple and cost-effective, opening the way for its application in artificial devices, such as the inner surfaces of tubes, medical devices, and heat exchangers.