Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host

Taro Ozaki, Atsushi Minami, Hideaki Oikawa

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Covering: 2013 to 2022 In this review, we provide an overview elucidating the biosynthetic pathway and heterologous production of fungal indole diterpenes (IDTs). Based on the studies of six IDT biosynthesis, we extracted nature's strategy: (1) two-stage synthesis for the core scaffold and platform intermediates, and (2) late-stage modifications for installing an additional cyclic system on the indole ring. Herein, we describe reconstitution studies applying this strategy to the synthesis of highly elaborated IDTs. We also discuss its potential for future biosynthetic engineering.

Original languageEnglish
Pages (from-to)202-213
Number of pages12
JournalNatural Product Reports
Volume40
Issue number1
DOIs
Publication statusPublished - 2022 Nov 2

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