Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis

Naoki Yoshimura; Tomohiko Oguchi; Hitoshi Yokoyama; Yasuhito Funahashi; Satoru Yoshikawa; Yoshio Sugino; Naoki Kawamorita; Mahendra P. Kashyap; Michael B. Chancellor; Pradeep Tyagi; Teruyuki Ogawa

doi:10.1111/iju.12308

Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis

Naoki Yoshimura, Tomohiko Oguchi, Hitoshi Yokoyama, Yasuhito Funahashi, Satoru Yoshikawa, Yoshio Sugino, Naoki Kawamorita, Mahendra P. Kashyap, Michael B. Chancellor, Pradeep Tyagi, Teruyuki Ogawa

Research output: Contribution to journal › Review article › peer-review

70 Citations (Scopus)

Abstract

Bladder pain syndrome/interstitial cystitis is a disease with lower urinary tract symptoms, such as bladder pain and urinary frequency, which results in seriously impaired quality of life of patients. The extreme pain and urinary frequency are often difficult to treat. Although the etiology of bladder pain syndrome/interstitial cystitis is still not known, there is increasing evidence showing that afferent hyperexcitability as a result of neurogenic bladder inflammation and urothelial dysfunction is important to the pathophysiological basis of symptom development. Further investigation of the pathophysiology will lead to the effective treatment of patients with bladder pain syndrome/interstitial cystitis.

Original language	English
Pages (from-to)	18-25
Number of pages	8
Journal	International Journal of Urology
Volume	21
Issue number	S1
DOIs	https://doi.org/10.1111/iju.12308
Publication status	Published - 2014 Apr
Externally published	Yes

Keywords

Afferent pathway
Bladder pain syndrome
Cytokine
Interstitial cystitis
Nerve growth factor

ASJC Scopus subject areas

Urology

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10.1111/iju.12308

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title = "Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis",

abstract = "Bladder pain syndrome/interstitial cystitis is a disease with lower urinary tract symptoms, such as bladder pain and urinary frequency, which results in seriously impaired quality of life of patients. The extreme pain and urinary frequency are often difficult to treat. Although the etiology of bladder pain syndrome/interstitial cystitis is still not known, there is increasing evidence showing that afferent hyperexcitability as a result of neurogenic bladder inflammation and urothelial dysfunction is important to the pathophysiological basis of symptom development. Further investigation of the pathophysiology will lead to the effective treatment of patients with bladder pain syndrome/interstitial cystitis.",

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AU - Yoshimura, Naoki

AU - Oguchi, Tomohiko

AU - Yokoyama, Hitoshi

AU - Funahashi, Yasuhito

AU - Yoshikawa, Satoru

AU - Sugino, Yoshio

AU - Kawamorita, Naoki

AU - Kashyap, Mahendra P.

AU - Chancellor, Michael B.

AU - Tyagi, Pradeep

AU - Ogawa, Teruyuki

PY - 2014/4

Y1 - 2014/4

N2 - Bladder pain syndrome/interstitial cystitis is a disease with lower urinary tract symptoms, such as bladder pain and urinary frequency, which results in seriously impaired quality of life of patients. The extreme pain and urinary frequency are often difficult to treat. Although the etiology of bladder pain syndrome/interstitial cystitis is still not known, there is increasing evidence showing that afferent hyperexcitability as a result of neurogenic bladder inflammation and urothelial dysfunction is important to the pathophysiological basis of symptom development. Further investigation of the pathophysiology will lead to the effective treatment of patients with bladder pain syndrome/interstitial cystitis.

AB - Bladder pain syndrome/interstitial cystitis is a disease with lower urinary tract symptoms, such as bladder pain and urinary frequency, which results in seriously impaired quality of life of patients. The extreme pain and urinary frequency are often difficult to treat. Although the etiology of bladder pain syndrome/interstitial cystitis is still not known, there is increasing evidence showing that afferent hyperexcitability as a result of neurogenic bladder inflammation and urothelial dysfunction is important to the pathophysiological basis of symptom development. Further investigation of the pathophysiology will lead to the effective treatment of patients with bladder pain syndrome/interstitial cystitis.

KW - Afferent pathway

KW - Bladder pain syndrome

KW - Cytokine

KW - Interstitial cystitis

KW - Nerve growth factor

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Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis

Abstract

Keywords

ASJC Scopus subject areas

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