Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis

Naoki Yoshimura, Tomohiko Oguchi, Hitoshi Yokoyama, Yasuhito Funahashi, Satoru Yoshikawa, Yoshio Sugino, Naoki Kawamorita, Mahendra P. Kashyap, Michael B. Chancellor, Pradeep Tyagi, Teruyuki Ogawa

Research output: Contribution to journalReview articlepeer-review

70 Citations (Scopus)


Bladder pain syndrome/interstitial cystitis is a disease with lower urinary tract symptoms, such as bladder pain and urinary frequency, which results in seriously impaired quality of life of patients. The extreme pain and urinary frequency are often difficult to treat. Although the etiology of bladder pain syndrome/interstitial cystitis is still not known, there is increasing evidence showing that afferent hyperexcitability as a result of neurogenic bladder inflammation and urothelial dysfunction is important to the pathophysiological basis of symptom development. Further investigation of the pathophysiology will lead to the effective treatment of patients with bladder pain syndrome/interstitial cystitis.

Original languageEnglish
Pages (from-to)18-25
Number of pages8
JournalInternational Journal of Urology
Issue numberS1
Publication statusPublished - 2014 Apr
Externally publishedYes


  • Afferent pathway
  • Bladder pain syndrome
  • Cytokine
  • Interstitial cystitis
  • Nerve growth factor

ASJC Scopus subject areas

  • Urology


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