Blood glucose measurement in vivo using hollow-fiber based, mid-infrared ATR probe with multi-reflection prism

Saiko Kino; Suguru Omori; Yuji Matsuura

doi:10.1117/12.2216652

Blood glucose measurement in vivo using hollow-fiber based, mid-infrared ATR probe with multi-reflection prism

Saiko Kino, Suguru Omori, Yuji Matsuura

MEN - Biomedical Engineering

Tohoku University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Citations (Scopus)

Abstract

An attenuated-total-reflection (ATR), mid-infrared spectroscopy system that consists of hollow optical fibers, a trapezoidal multi-reflection ATR prism, and a conventional FT-IR spectrometer has been developed to measure blood glucose levels. Owing to the low transmission loss and high flexibility of the hollow-optical fiber, the system can measure any sites of the human body where blood capillaries are close to the surface of mucosa, such as inner lips. Using a multi-reflection prism brought about higher sensitivity, and the flat and wide contact surface of the prism resulted in higher measurement reproducibility. The results of in-vivo measurement of human inner lips showed the feasibility of the proposed system, and the measurement errors were within 20%.

Original language	English
Title of host publication	Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI
Editors	Israel Gannot
Publisher	SPIE
ISBN (Electronic)	9781628419368
DOIs	https://doi.org/10.1117/12.2216652
Publication status	Published - 2016
Event	Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI - San Francisco, United States Duration: 2016 Feb 13 → 2016 Feb 14

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9702
ISSN (Print)	1605-7422

Conference

Conference	Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI
Country/Territory	United States
City	San Francisco
Period	16/2/13 → 16/2/14

Keywords

Blood glucose measurement
hollow optical fibers
infrared spectroscopy

Access to Document

10.1117/12.2216652

Cite this

Kino, S., Omori, S., & Matsuura, Y. (2016). Blood glucose measurement in vivo using hollow-fiber based, mid-infrared ATR probe with multi-reflection prism. In I. Gannot (Ed.), Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI Article 970209 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9702). SPIE. https://doi.org/10.1117/12.2216652

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title = "Blood glucose measurement in vivo using hollow-fiber based, mid-infrared ATR probe with multi-reflection prism",

abstract = "An attenuated-total-reflection (ATR), mid-infrared spectroscopy system that consists of hollow optical fibers, a trapezoidal multi-reflection ATR prism, and a conventional FT-IR spectrometer has been developed to measure blood glucose levels. Owing to the low transmission loss and high flexibility of the hollow-optical fiber, the system can measure any sites of the human body where blood capillaries are close to the surface of mucosa, such as inner lips. Using a multi-reflection prism brought about higher sensitivity, and the flat and wide contact surface of the prism resulted in higher measurement reproducibility. The results of in-vivo measurement of human inner lips showed the feasibility of the proposed system, and the measurement errors were within 20%.",

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author = "Saiko Kino and Suguru Omori and Yuji Matsuura",

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Kino, S, Omori, S & Matsuura, Y 2016, Blood glucose measurement in vivo using hollow-fiber based, mid-infrared ATR probe with multi-reflection prism. in I Gannot (ed.), Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI., 970209, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9702, SPIE, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI, San Francisco, United States, 16/2/13. https://doi.org/10.1117/12.2216652

Blood glucose measurement in vivo using hollow-fiber based, mid-infrared ATR probe with multi-reflection prism. / Kino, Saiko; Omori, Suguru; Matsuura, Yuji.
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI. ed. / Israel Gannot. SPIE, 2016. 970209 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9702).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Kino, Saiko

AU - Omori, Suguru

AU - Matsuura, Yuji

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N2 - An attenuated-total-reflection (ATR), mid-infrared spectroscopy system that consists of hollow optical fibers, a trapezoidal multi-reflection ATR prism, and a conventional FT-IR spectrometer has been developed to measure blood glucose levels. Owing to the low transmission loss and high flexibility of the hollow-optical fiber, the system can measure any sites of the human body where blood capillaries are close to the surface of mucosa, such as inner lips. Using a multi-reflection prism brought about higher sensitivity, and the flat and wide contact surface of the prism resulted in higher measurement reproducibility. The results of in-vivo measurement of human inner lips showed the feasibility of the proposed system, and the measurement errors were within 20%.

AB - An attenuated-total-reflection (ATR), mid-infrared spectroscopy system that consists of hollow optical fibers, a trapezoidal multi-reflection ATR prism, and a conventional FT-IR spectrometer has been developed to measure blood glucose levels. Owing to the low transmission loss and high flexibility of the hollow-optical fiber, the system can measure any sites of the human body where blood capillaries are close to the surface of mucosa, such as inner lips. Using a multi-reflection prism brought about higher sensitivity, and the flat and wide contact surface of the prism resulted in higher measurement reproducibility. The results of in-vivo measurement of human inner lips showed the feasibility of the proposed system, and the measurement errors were within 20%.

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KW - hollow optical fibers

KW - infrared spectroscopy

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Blood glucose measurement in vivo using hollow-fiber based, mid-infrared ATR probe with multi-reflection prism

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