@inproceedings{7c782a006cfc4d23b8986d357cf1063e,
title = "Blood glucose measurement with multiple quantum cascade lasers using hollow-optical fiber-based ATR spectroscopy",
abstract = "For non-invasive blood glucose measurement, a measurement system based on mid-infrared ATR spectroscopy equipped with a combination of a QCL as a light source and a hollow-optical fiber as a beam delivery medium is developed. Firstly the measurement sensitivity of the system is evaluated by using glucose solutions and the result shows a significant correlation between optical absorbance and solution concentration. It is also confirmed that the system has a sensitivity that is enough for blood glucose measurement. Then optical absorption of human lips in the mid-infrared wavelength region is measured using a QCL with a wavenumber of 1080 cm-1 where human tissue exhibits strong absorption of glucose and its metabolites. As a result, the measured absorption follows the change of blood glucose well with a time delay of around 10 minutes and correlation factor between the absorbance and the blood glucose level is 0.42.",
keywords = "ATR spectroscopy, blood glucose, hollow-optical fiber, quantum cascade laser",
author = "K. Yoshioka and S. Kino and Y. Matsuura",
year = "2018",
month = jan,
day = "1",
doi = "10.1117/12.2288131",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Israel Gannot and Israel Gannot",
booktitle = "Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII",
note = "Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII 2018 ; Conference date: 27-01-2018 Through 28-01-2018",
}