Blood oxygenation using microbubble suspensions

Noriaki Matsuki, Shingo Ichiba, Takuji Ishikawa, Osamu Nagano, Motohiro Takeda, Yoshihito Ujike, Takami Yamaguchi

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Microbubbles have been used in a variety of fields and have unique properties, for example shrinking collapse, long lifetime, efficient gas solubility, a negatively charged surface, and the ability to produce free radicals. In medicine, microbubbles have been used mainly as diagnostic aids to scan various organs of the body, and they have recently been investigated for use in drug and gene delivery. However, there have been no reports of blood oxygenation by use of oxygen microbubble fluids without shell reagents. In this study, we demonstrated that nano or microbubbles can achieve oxygen supersaturation of fluids, and may be sufficiently small and safe for infusion into blood vessels. Although Po2 increases in fluids resulting from use of microbubbles were inhibited by polar solvents, normal saline solution (NSS) was little affected. Thus, NSS is suitable for production of oxygen-rich fluid. In addition, oxygen microbubble NSS effectively improved hypoxic conditions in blood. Thus, use of oxygen microbubble (nanobubble) fluids is a potentially effective novel method for oxygenation of hypoxic tissues, for infection control, and for anticancer treatment.

Original languageEnglish
Pages (from-to)571-578
Number of pages8
JournalEuropean Biophysics Journal
Issue number6
Publication statusPublished - 2012 Jun


  • Fluid oxygenation
  • Microbubble
  • Microbubble fluid
  • Nanobubble
  • Oxygenation


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