The present study was done to investigate the role of endogenous prostaglandins and kinins in the mechanism of captopril-induced hypotensive effect and stimulating effect of plasma renin activity (PRA) in pentobarbital-anesthetized rats. An intravenous injection of 1 mg/kg captopril significantly decreased mean blood pressure (MBP) and raised PRA. In indomethacin (5 mg/kg i.v.)- or aprotinin (50,000 kallikrein inhibitory units/kg and subsequent 100 k.i.u./kg·min, i.v.)-pretreated rats, MBP reduction and elevation of PRA induced by captopril were similar to those in the non-pretreated animals throughout the experimental periods. These results suggest that prostaglandins and/or the kallikrein-kinin system do not substantially participate in the captopril-induced hypotension and renin release under the present experimental conditions.
|Number of pages||11|
|Journal||Archives Internationales de Pharmacodynamie et de Therapie|
|Publication status||Published - 1985 Dec 1|
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