Blood pressure measured in the clinic and at home during pregnancy among nulliparous and multiparous women: The BOSHI study

Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Mami Yamamoto, Konomi Akutsu, Kasumi Sakurai, Noriyuki Iwama, Mikiko Katagiri, Katsuyo Yagihashi, Nobuo Yaegashi, Shigeru Mori, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Background Hypertension during pregnancy can cause serious problems during delivery, such as stroke, premature delivery, or low birthweight. Nulliparity is believed to be a risk factor for hypertension during pregnancy. However, the relationship between parity and blood pressure determined at home during pregnancy is still unknown. Methods We assessed the incidence of gestational hypertension or preeclampsia in 575 nulliparous and multiparous women. Also, we examined blood pressure measured in the clinic and at home among 530 normotensive pregnant women who received antenatal care at a maternity hospital in Japan. Clinic blood pressures (CBPs) were obtained by duplicate measurement at each antenatal care visit. The participants were also required to measure their own blood pressures every morning at home while they were pregnant. A linear mixed model was used for analysis of the blood pressure course throughout pregnancy. Results A total of 315 nulliparous and 215 multiparous women were entered into this study (mean age, 30.1±4.6 years and 33.0±4.1 years, respectively). CBP levels during pregnancy among nulliparous women were significantly higher than among multiparous women (P = 0.02/P <0.0001 for systolic/diastolic blood pressure), whereas there were no significant differences in home blood pressure (HBP) levels during pregnancy between the two groups (P = 0.4/P = 0.2 for systolic/diastolic blood pressure). Conclusions HBP levels during pregnancy were shown not to differ between nulliparous and multiparous women, while CBP levels during pregnancy were higher among nulliparous than among multiparous women.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalAmerican Journal of Hypertension
Issue number1
Publication statusPublished - 2013 Jan


  • blood pressure
  • clinic blood pressure
  • home blood pressure
  • hypertension
  • parity
  • pregnancy


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