BODIPY-based probes for the fluorescence imaging of biomolecules in living cells

Toshiyuki Kowada, Hiroki Maeda, Kazuya Kikuchi

Research output: Contribution to journalReview articlepeer-review

1067 Citations (Scopus)


Fluorescence imaging techniques have been widely used to visualize biological molecules and phenomena. In particular, several studies on the development of small-molecule fluorescent probes have been carried out, because their fluorescence properties can be easily tuned by synthetic chemical modification. For this reason, various fluorescent probes have been developed for targeting biological components, such as proteins, peptides, amino acids, and ions, to the interior and exterior of cells. In this review, we cover advances in the development of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based fluorescent probes for biological studies over the past decade.

Original languageEnglish
Pages (from-to)4953-4972
Number of pages20
JournalChemical Society Reviews
Issue number14
Publication statusPublished - 2015 Jul 21


Dive into the research topics of 'BODIPY-based probes for the fluorescence imaging of biomolecules in living cells'. Together they form a unique fingerprint.

Cite this