TY - JOUR
T1 - Bonding of synthetic hydrogels with fibrin as the glue to engineer hydrogel-based biodevices
AU - Nagamine, Kuniaki
AU - Okamoto, Kohei
AU - Kaji, Hirokazu
AU - Nishizawa, Matsuhiko
N1 - Funding Information:
We would like to thank Professor T. Yokobori and Dr. T. Ohmi who provide their axial-loading apparatus and technical advices. This work was partly supported by Regional Innovation Strategy Support Program “Knowledge-based Medical Device Cluster/Miyagi Area”, Creation of Innovation Centers for Advanced Interdisciplinary Research Area “R&D Center of Excellence for Integrated Microsystems Tohoku University” from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2014/7
Y1 - 2014/7
N2 - We show the fibrous protein fibrin can serve as biocompatible glue with which to bind synthetic cationic or anionic hydrogels together. Both the bonding to and detachment from the hydrogels by fibrin (gelation and degradation, respectively) proceeded enzymatically under physiological conditions. We built a hydrogel-based actuator to demonstrate the method.
AB - We show the fibrous protein fibrin can serve as biocompatible glue with which to bind synthetic cationic or anionic hydrogels together. Both the bonding to and detachment from the hydrogels by fibrin (gelation and degradation, respectively) proceeded enzymatically under physiological conditions. We built a hydrogel-based actuator to demonstrate the method.
KW - Biocompatible glue
KW - Fibrin
KW - Hydrogel-based biodevice
KW - Tissue engineering
KW - Wet adhesion technique
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U2 - 10.1016/j.jbiosc.2013.12.024
DO - 10.1016/j.jbiosc.2013.12.024
M3 - Article
C2 - 24495925
AN - SCOPUS:84903197977
SN - 1389-1723
VL - 118
SP - 94
EP - 97
JO - Journal of Bioscience and Bioengineering
JF - Journal of Bioscience and Bioengineering
IS - 1
ER -