Bone cartilage imaging with X-ray interferometry using a practical X-ray tube

Kazuhiro Kido, Chiho Makifuchi, Junko Kiyohara, Tsukasa Itou, Chika Honda, Atsushi Momose

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)


The purpose of this study was to design an X-ray Talbot-Lau interferometer for the imaging of bone cartilage using a practical X-ray tube and to develop that imaging system for clinical use. Wave-optics simulation was performed to design the interferometer with a practical X-ray tube, a source grating, two X-ray gratings, and an X-ray detector. An imaging system was created based on the results of the simulation. The specifications were as follows: the focal spot size was 0.3 mm of an X-ray tube with a tungsten anode (Toshiba, Tokyo, Japan). The tube voltage was set at 40 kVp with an additive aluminum filter, and the mean energy was 31 keV. The pixel size of the X-ray detector, a Condor 486 (Fairchild Imaging, California, USA), was 15μm. The second grating was a Ronchi-type grating whose pitch was 5.3μm. Imaging performance of the system was examined with X-ray doses of 0.5, 3 and 9 mGy so that the bone cartilage of a chicken wing was clearly depicted with X-ray doses of 3 and 9 mGy. This was consistent with the simulation's predictions. The results suggest that X-ray Talbot-Lau interferometry would be a promising tool in detecting soft tissues in the human body such as bone cartilage for the X-ray image diagnosis of rheumatoid arthritis. Further optimization of the system will follow to reduce the X-ray dose for clinical use.

Original languageEnglish
Title of host publicationMedical Imaging 2010
Subtitle of host publicationPhysics of Medical Imaging
EditionPART 3
Publication statusPublished - 2010 Dec 1
Externally publishedYes
EventMedical Imaging 2010: Physics of Medical Imaging - San Diego, CA, United States
Duration: 2010 Feb 152010 Feb 18

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 3
ISSN (Print)1605-7422


OtherMedical Imaging 2010: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • Bone cartilage
  • Grating interferometry
  • Medical imaging
  • Phase-contrast imaging
  • Small-angle scattering image
  • Talbot-Lau interferometry

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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