TY - JOUR
T1 - Bone regeneration by octacalcium phosphate collagen composites in a dog alveolar cleft model
AU - Matsui, K.
AU - Matsui, A.
AU - Handa, T.
AU - Kawai, T.
AU - Suzuki, O.
AU - Kamakura, S.
AU - Echigo, S.
N1 - Funding Information:
Although this study was supported in part by grants-in aid ( 16591979 , 17076001 , 20300165 , 21592568) from the Ministry of Education, Science, Sports and Culture of Japan , and grants from the Japan Science and Technology Agency , Mitsui Sumitomo Insurance Welfare Foundation , and Daiwa Securities Health Foundation , these study sponsors had no involvement in the study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.
PY - 2010/12
Y1 - 2010/12
N2 - Octacalcium phosphate (OCP) and porcine atelocollagen sponge composites (OCP/Col) markedly enhanced bone regeneration in a rat cranial defect model. To assess clinical application, the authors examined whether OCP/Col would enhance bone regeneration in an alveolar cleft model in an adult dog, which was assumed to reflect patients with alveolar cleft. Disks of OCP/Col or collagen were implanted into the defect and bone regeneration by OCP/Col or collagen was investigated 4 months after implantation. Macroscopically, the OCP/Col-treated alveolus was obviously augmented and occupied by radio-opacity, and the border between the original bone and the defect was indistinguishable. Histological analysis revealed it was filled and bridged with newly formed bone; a small quantity of the remaining implanted OCP was observed. X-ray diffraction patterns of the area of implanted OCP/Col indicated no difference from those of dog bone. In the collagen-treated alveolus, the hollowed alveolus was mainly filled with fibrous connective tissue, and a small amount of new bone was observed at the defect margin. These results suggest that bone was obviously repaired when OCP/Col was implanted into the alveolar cleft model in a dog, and OCP/Col would be a significant bone regenerative material to substitute for autogeneous bone.
AB - Octacalcium phosphate (OCP) and porcine atelocollagen sponge composites (OCP/Col) markedly enhanced bone regeneration in a rat cranial defect model. To assess clinical application, the authors examined whether OCP/Col would enhance bone regeneration in an alveolar cleft model in an adult dog, which was assumed to reflect patients with alveolar cleft. Disks of OCP/Col or collagen were implanted into the defect and bone regeneration by OCP/Col or collagen was investigated 4 months after implantation. Macroscopically, the OCP/Col-treated alveolus was obviously augmented and occupied by radio-opacity, and the border between the original bone and the defect was indistinguishable. Histological analysis revealed it was filled and bridged with newly formed bone; a small quantity of the remaining implanted OCP was observed. X-ray diffraction patterns of the area of implanted OCP/Col indicated no difference from those of dog bone. In the collagen-treated alveolus, the hollowed alveolus was mainly filled with fibrous connective tissue, and a small amount of new bone was observed at the defect margin. These results suggest that bone was obviously repaired when OCP/Col was implanted into the alveolar cleft model in a dog, and OCP/Col would be a significant bone regenerative material to substitute for autogeneous bone.
KW - Alveolar cleft
KW - Bone regeneration
KW - Collagen
KW - Dog
KW - Octacalcium phosphate
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U2 - 10.1016/j.ijom.2010.07.015
DO - 10.1016/j.ijom.2010.07.015
M3 - Article
C2 - 20863660
AN - SCOPUS:78649661556
SN - 0901-5027
VL - 39
SP - 1218
EP - 1225
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
IS - 12
ER -