Bone regeneration by octacalcium phosphate collagen composites in a dog alveolar cleft model

K. Matsui, A. Matsui, T. Handa, T. Kawai, O. Suzuki, S. Kamakura, S. Echigo

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Octacalcium phosphate (OCP) and porcine atelocollagen sponge composites (OCP/Col) markedly enhanced bone regeneration in a rat cranial defect model. To assess clinical application, the authors examined whether OCP/Col would enhance bone regeneration in an alveolar cleft model in an adult dog, which was assumed to reflect patients with alveolar cleft. Disks of OCP/Col or collagen were implanted into the defect and bone regeneration by OCP/Col or collagen was investigated 4 months after implantation. Macroscopically, the OCP/Col-treated alveolus was obviously augmented and occupied by radio-opacity, and the border between the original bone and the defect was indistinguishable. Histological analysis revealed it was filled and bridged with newly formed bone; a small quantity of the remaining implanted OCP was observed. X-ray diffraction patterns of the area of implanted OCP/Col indicated no difference from those of dog bone. In the collagen-treated alveolus, the hollowed alveolus was mainly filled with fibrous connective tissue, and a small amount of new bone was observed at the defect margin. These results suggest that bone was obviously repaired when OCP/Col was implanted into the alveolar cleft model in a dog, and OCP/Col would be a significant bone regenerative material to substitute for autogeneous bone.

Original languageEnglish
Pages (from-to)1218-1225
Number of pages8
JournalInternational Journal of Oral and Maxillofacial Surgery
Issue number12
Publication statusPublished - 2010 Dec


  • Alveolar cleft
  • Bone regeneration
  • Collagen
  • Dog
  • Octacalcium phosphate

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology


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