Brain metabolic changes of cervical dystonia with spinocerebellar ataxia type 1 after botulinum toxin therapy

Akio Kikuchi; Atsushi Takeda; Naoto Sugeno; Emiko Miura; Kazuhiro Kato; Takafumi Hasegaw; Toru Baba; Masatoshi Konno; Ryuji Oshima; Shoichi Watanuki; Kotaro Hiraoka; Manabu Tashiro; Masashi Aoki

doi:10.2169/internalmedicine.55.5843

Brain metabolic changes of cervical dystonia with spinocerebellar ataxia type 1 after botulinum toxin therapy

Akio Kikuchi, Atsushi Takeda, Naoto Sugeno, Emiko Miura, Kazuhiro Kato, Takafumi Hasegaw, Toru Baba, Masatoshi Konno, Ryuji Oshima, Shoichi Watanuki, Kotaro Hiraoka, Manabu Tashiro, Masashi Aoki

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We occasionally observe long-term remission of cervical dystonia after several botulinum toxin treatments. However, botulinum toxin transiently acts on neuromuscular junctions. We herein report that a cervical dystonia patient with spinocerebellar ataxia type 1 could have long-term remission as a result of the depression of hypermetabolism in the bilateral putamen and primary sensorimotor cortex after botulinum toxin therapy. We suggest that botulinum toxin impacts the central nervous system, causing prolonged improvement through the normalization of basal ganglia circuits in addition to its effects at neuromuscular junctions.

Original language	English
Pages (from-to)	1919-1922
Number of pages	4
Journal	Internal Medicine
Volume	55
Issue number	14
DOIs	https://doi.org/10.2169/internalmedicine.55.5843
Publication status	Published - 2016

Keywords

Basal ganglia circuits
Botulinum toxin treatment
Cervical dystonia
Positron emission tomography (PET)
Spinocerebellar ataxia type 1 (SCA1)

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10.2169/internalmedicine.55.5843

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title = "Brain metabolic changes of cervical dystonia with spinocerebellar ataxia type 1 after botulinum toxin therapy",

abstract = "We occasionally observe long-term remission of cervical dystonia after several botulinum toxin treatments. However, botulinum toxin transiently acts on neuromuscular junctions. We herein report that a cervical dystonia patient with spinocerebellar ataxia type 1 could have long-term remission as a result of the depression of hypermetabolism in the bilateral putamen and primary sensorimotor cortex after botulinum toxin therapy. We suggest that botulinum toxin impacts the central nervous system, causing prolonged improvement through the normalization of basal ganglia circuits in addition to its effects at neuromuscular junctions.",

keywords = "Basal ganglia circuits, Botulinum toxin treatment, Cervical dystonia, Positron emission tomography (PET), Spinocerebellar ataxia type 1 (SCA1)",

author = "Akio Kikuchi and Atsushi Takeda and Naoto Sugeno and Emiko Miura and Kazuhiro Kato and Takafumi Hasegaw and Toru Baba and Masatoshi Konno and Ryuji Oshima and Shoichi Watanuki and Kotaro Hiraoka and Manabu Tashiro and Masashi Aoki",

note = "Funding Information: This work was supported in part by Takeda Science Foundation of Japan, Grants-in-Aid from the Research Committee of Dystonia, the Ministry of Health, Labour and Welfare of Japan, and Grants-in-Aid for Scientific Research (C) (23591266, 26461303) from The Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. Publisher Copyright: {\textcopyright} 2016 The Japanese Society of Internal Medicine.",

year = "2016",

doi = "10.2169/internalmedicine.55.5843",

language = "English",

volume = "55",

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T1 - Brain metabolic changes of cervical dystonia with spinocerebellar ataxia type 1 after botulinum toxin therapy

AU - Kikuchi, Akio

AU - Takeda, Atsushi

AU - Sugeno, Naoto

AU - Miura, Emiko

AU - Kato, Kazuhiro

AU - Hasegaw, Takafumi

AU - Baba, Toru

AU - Konno, Masatoshi

AU - Oshima, Ryuji

AU - Watanuki, Shoichi

AU - Hiraoka, Kotaro

AU - Tashiro, Manabu

AU - Aoki, Masashi

N1 - Funding Information: This work was supported in part by Takeda Science Foundation of Japan, Grants-in-Aid from the Research Committee of Dystonia, the Ministry of Health, Labour and Welfare of Japan, and Grants-in-Aid for Scientific Research (C) (23591266, 26461303) from The Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. Publisher Copyright: © 2016 The Japanese Society of Internal Medicine.

PY - 2016

Y1 - 2016

N2 - We occasionally observe long-term remission of cervical dystonia after several botulinum toxin treatments. However, botulinum toxin transiently acts on neuromuscular junctions. We herein report that a cervical dystonia patient with spinocerebellar ataxia type 1 could have long-term remission as a result of the depression of hypermetabolism in the bilateral putamen and primary sensorimotor cortex after botulinum toxin therapy. We suggest that botulinum toxin impacts the central nervous system, causing prolonged improvement through the normalization of basal ganglia circuits in addition to its effects at neuromuscular junctions.

AB - We occasionally observe long-term remission of cervical dystonia after several botulinum toxin treatments. However, botulinum toxin transiently acts on neuromuscular junctions. We herein report that a cervical dystonia patient with spinocerebellar ataxia type 1 could have long-term remission as a result of the depression of hypermetabolism in the bilateral putamen and primary sensorimotor cortex after botulinum toxin therapy. We suggest that botulinum toxin impacts the central nervous system, causing prolonged improvement through the normalization of basal ganglia circuits in addition to its effects at neuromuscular junctions.

KW - Basal ganglia circuits

KW - Botulinum toxin treatment

KW - Cervical dystonia

KW - Positron emission tomography (PET)

KW - Spinocerebellar ataxia type 1 (SCA1)

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Brain metabolic changes of cervical dystonia with spinocerebellar ataxia type 1 after botulinum toxin therapy

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