Bruchpilot, A synaptic active zone protein for anesthesia-resistant memory

Stephan Knapek, Stephan Sigrist, Hiromu Tanimoto

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


In Drosophila, aversive associative memory of an odor consists of heterogeneous components with different stabilities. Here we report that Bruchpilot (Brp), a ubiquitous presynaptic active zone protein, is required for olfactory memory. Brp was shown before to facilitate efficient vesicle release, particularly at low stimulation frequencies. Transgenic knockdown in the Kenyon cells of the mushroom body, the second-order olfactory interneurons, revealed that Brp is required for olfactory memory. We further demonstrate that Brp in the Kenyon cells preferentially functions for anesthesia-resistant memory. Another presynaptic protein, Synapsin, was shown previously to be required selectively for the labile anesthesia-sensitive memory, which is less affected in brp knockdown. Thus, consolidated and labile components of aversive olfactory memory can be dissociated by the function of different presynaptic proteins.

Original languageEnglish
Pages (from-to)3453-3458
Number of pages6
JournalJournal of Neuroscience
Issue number9
Publication statusPublished - 2011 Mar 2
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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