Bullous pemphigoid accompanied by aplastic anemia: The induction of IL-17-producing cells in the affected areas of the skin

Taku Fujimura; Aya Kakizaki; Yumi Kambayashi; Sadanori Furudate; Setsuya Aiba

doi:10.1159/000343882

Bullous pemphigoid accompanied by aplastic anemia: The induction of IL-17-producing cells in the affected areas of the skin

Taku Fujimura, Aya Kakizaki, Yumi Kambayashi, Sadanori Furudate, Setsuya Aiba

MED - Medical Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Th17 cells, characterized by IL-17 production, play a critical role in the pathogenesis of autoimmune diseases, including autoimmune bullous disorders and aplastic anemia (AA). In this report, we describe a 58-year-old Japanese man with bullous pemphigoid (BP) accompanied by AA. Interestingly, immunohistochemical staining revealed the existence of IL-17-producing cells in the skin biopsy specimens from BP. Our findings might suggest relationships between IL-17 and the pathogenesis of these autoimmune diseases, and, to our knowledge, this is the first English report of BP accompanied by AA.

Original language	English
Pages (from-to)	211-214
Number of pages	4
Journal	Case Reports in Dermatology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1159/000343882
Publication status	Published - 2012 Apr 20

Keywords

Aplastic anemia
Bullous pemphigoid
IL-17

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10.1159/000343882

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title = "Bullous pemphigoid accompanied by aplastic anemia: The induction of IL-17-producing cells in the affected areas of the skin",

abstract = "Th17 cells, characterized by IL-17 production, play a critical role in the pathogenesis of autoimmune diseases, including autoimmune bullous disorders and aplastic anemia (AA). In this report, we describe a 58-year-old Japanese man with bullous pemphigoid (BP) accompanied by AA. Interestingly, immunohistochemical staining revealed the existence of IL-17-producing cells in the skin biopsy specimens from BP. Our findings might suggest relationships between IL-17 and the pathogenesis of these autoimmune diseases, and, to our knowledge, this is the first English report of BP accompanied by AA.",

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T2 - The induction of IL-17-producing cells in the affected areas of the skin

AU - Fujimura, Taku

AU - Kakizaki, Aya

AU - Kambayashi, Yumi

AU - Furudate, Sadanori

AU - Aiba, Setsuya

PY - 2012/4/20

Y1 - 2012/4/20

N2 - Th17 cells, characterized by IL-17 production, play a critical role in the pathogenesis of autoimmune diseases, including autoimmune bullous disorders and aplastic anemia (AA). In this report, we describe a 58-year-old Japanese man with bullous pemphigoid (BP) accompanied by AA. Interestingly, immunohistochemical staining revealed the existence of IL-17-producing cells in the skin biopsy specimens from BP. Our findings might suggest relationships between IL-17 and the pathogenesis of these autoimmune diseases, and, to our knowledge, this is the first English report of BP accompanied by AA.

AB - Th17 cells, characterized by IL-17 production, play a critical role in the pathogenesis of autoimmune diseases, including autoimmune bullous disorders and aplastic anemia (AA). In this report, we describe a 58-year-old Japanese man with bullous pemphigoid (BP) accompanied by AA. Interestingly, immunohistochemical staining revealed the existence of IL-17-producing cells in the skin biopsy specimens from BP. Our findings might suggest relationships between IL-17 and the pathogenesis of these autoimmune diseases, and, to our knowledge, this is the first English report of BP accompanied by AA.

KW - Aplastic anemia

KW - Bullous pemphigoid

KW - IL-17

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Bullous pemphigoid accompanied by aplastic anemia: The induction of IL-17-producing cells in the affected areas of the skin

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