Cadmium-Induced Dental Lesions in Ovariectomized Rats

Osamu Katsuta, Hideaki Hiratsuka, Junko Matsumoto, Minoru Tsuchitani, Takashi Umemura

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The effects of cadmium chloride on both incisor and molar teeth of ovariectomized female rats were studied histopathologically. The rats were injected intravenously with the compound at doses of 1.0 and 2.0 mg/kg, 5 days/wk. Six rats per group were sacrificed at 4, 8, and 13 wk. Discoloration of the incisors was observed in the rats of the 2.0-mg/kg group from 8 wk. Histopathologic examination of the incisor demonstrated decreased iron-containing pigment in ameloblasts and destruction of the enamel organ. These changes were accompanied with accumulation of cadmium and loss of iron in the teeth. Necrosis of the dental pulp occurred from the coronal end of both the incisor and molar teeth extended to the apical, deep portion of the teeth. The dental pulp of the molar teeth, which is shorter than that of the incisor, was mildly affected by cadmium intoxication. These findings suggested that intradental ischemia due to cadmium toxicity may have contributed to the development of the pulpal necrosis.

Original languageEnglish
Pages (from-to)451-457
Number of pages7
JournalToxicologic Pathology
Issue number4
Publication statusPublished - 1996 Jul
Externally publishedYes


  • Cadmium toxicity
  • degeneration of enamel organ
  • incisor and molar teeth
  • Itai-itai disease
  • necrosis of dental pulp

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology


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