Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear

Masashi Koto; Azusa Hasegawa; Ryo Takagi; Go Sasahara; Hiroaki Ikawa; Jun Etsu Mizoe; Keiichi Jingu; Hirohiko Tsujii; Tadashi Kamada; Yoshitaka Okamoto

doi:10.1002/hed.23905

Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear

Masashi Koto, Azusa Hasegawa, Ryo Takagi, Go Sasahara, Hiroaki Ikawa, Jun Etsu Mizoe, Keiichi Jingu, Hirohiko Tsujii, Tadashi Kamada, Yoshitaka Okamoto

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background The prognosis of advanced squamous cell carcinoma (SCC) of the external auditory canal and middle ear remains poor. Carbon ion radiotherapy (C-ion RT) has shown promise for locally advanced head and neck cancer. Therefore, we evaluated the safety and efficacy of C-ion RT for locally advanced SCC of the external auditory canal and middle ear. Methods The cases of 13 patients with advanced (T3 and T4) SCC of the external auditory canal and middle ear who received C-ion RT as the primary treatment were reviewed. Results The median follow-up for all patients and the 7 surviving patients was 12 and 32 months, respectively. The 1-year and 3-year local control and overall survival (OS) rates were 72% and 54% and 70% and 40%, respectively. Severe temporal bone necrosis was observed in 2 patients. Conclusion C-ion RT is effective and generally safe for locally advanced SCC of the external auditory canal and middle ear.

Original language	English
Pages (from-to)	512-516
Number of pages	5
Journal	Head and Neck
Volume	38
Issue number	4
DOIs	https://doi.org/10.1002/hed.23905
Publication status	Published - 2016 Apr 1

Keywords

carbon ion radiotherapy
external auditory canal
middle ear
squamous cell carcinoma
temporal bone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/hed.23905

Cite this

@article{a31870c2bc8b4dd080c0d326bdf186f1,

title = "Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear",

abstract = "Background The prognosis of advanced squamous cell carcinoma (SCC) of the external auditory canal and middle ear remains poor. Carbon ion radiotherapy (C-ion RT) has shown promise for locally advanced head and neck cancer. Therefore, we evaluated the safety and efficacy of C-ion RT for locally advanced SCC of the external auditory canal and middle ear. Methods The cases of 13 patients with advanced (T3 and T4) SCC of the external auditory canal and middle ear who received C-ion RT as the primary treatment were reviewed. Results The median follow-up for all patients and the 7 surviving patients was 12 and 32 months, respectively. The 1-year and 3-year local control and overall survival (OS) rates were 72% and 54% and 70% and 40%, respectively. Severe temporal bone necrosis was observed in 2 patients. Conclusion C-ion RT is effective and generally safe for locally advanced SCC of the external auditory canal and middle ear.",

keywords = "carbon ion radiotherapy, external auditory canal, middle ear, squamous cell carcinoma, temporal bone",

author = "Masashi Koto and Azusa Hasegawa and Ryo Takagi and Go Sasahara and Hiroaki Ikawa and Mizoe, {Jun Etsu} and Keiichi Jingu and Hirohiko Tsujii and Tadashi Kamada and Yoshitaka Okamoto",

note = "Publisher Copyright: {\textcopyright} 2015 Wiley Periodicals, Inc.",

year = "2016",

month = apr,

day = "1",

doi = "10.1002/hed.23905",

language = "English",

volume = "38",

pages = "512--516",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "4",

}

TY - JOUR

T1 - Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear

AU - Koto, Masashi

AU - Hasegawa, Azusa

AU - Takagi, Ryo

AU - Sasahara, Go

AU - Ikawa, Hiroaki

AU - Mizoe, Jun Etsu

AU - Jingu, Keiichi

AU - Tsujii, Hirohiko

AU - Kamada, Tadashi

AU - Okamoto, Yoshitaka

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background The prognosis of advanced squamous cell carcinoma (SCC) of the external auditory canal and middle ear remains poor. Carbon ion radiotherapy (C-ion RT) has shown promise for locally advanced head and neck cancer. Therefore, we evaluated the safety and efficacy of C-ion RT for locally advanced SCC of the external auditory canal and middle ear. Methods The cases of 13 patients with advanced (T3 and T4) SCC of the external auditory canal and middle ear who received C-ion RT as the primary treatment were reviewed. Results The median follow-up for all patients and the 7 surviving patients was 12 and 32 months, respectively. The 1-year and 3-year local control and overall survival (OS) rates were 72% and 54% and 70% and 40%, respectively. Severe temporal bone necrosis was observed in 2 patients. Conclusion C-ion RT is effective and generally safe for locally advanced SCC of the external auditory canal and middle ear.

AB - Background The prognosis of advanced squamous cell carcinoma (SCC) of the external auditory canal and middle ear remains poor. Carbon ion radiotherapy (C-ion RT) has shown promise for locally advanced head and neck cancer. Therefore, we evaluated the safety and efficacy of C-ion RT for locally advanced SCC of the external auditory canal and middle ear. Methods The cases of 13 patients with advanced (T3 and T4) SCC of the external auditory canal and middle ear who received C-ion RT as the primary treatment were reviewed. Results The median follow-up for all patients and the 7 surviving patients was 12 and 32 months, respectively. The 1-year and 3-year local control and overall survival (OS) rates were 72% and 54% and 70% and 40%, respectively. Severe temporal bone necrosis was observed in 2 patients. Conclusion C-ion RT is effective and generally safe for locally advanced SCC of the external auditory canal and middle ear.

KW - carbon ion radiotherapy

KW - external auditory canal

KW - middle ear

KW - squamous cell carcinoma

KW - temporal bone

UR - http://www.scopus.com/inward/record.url?scp=84930079107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930079107&partnerID=8YFLogxK

U2 - 10.1002/hed.23905

DO - 10.1002/hed.23905

M3 - Article

C2 - 25352333

AN - SCOPUS:84930079107

SN - 1043-3074

VL - 38

SP - 512

EP - 516

JO - Head and Neck

JF - Head and Neck

IS - 4

ER -

Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this