Carbonyl stress and diabetic complications

Toshio Miyata, Naoyoshi Ishikawa, Charles van Ypersele de Strihou

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)


Advanced glycation irreversibly and progressively modifies proteins over time and yields the advanced glycation end-products (AGE). AGEs are thought to contribute to the development of atherosclerosis and of diabetic and uremic complications. Their inhibition has thus become a therapeutic goal. In this article, we discuss the role of various reactive carbonyl compound (RCOs) in the genesis of AGEs, postulate the existence of "carbonyl stress" in complicated diabetes and, finally, discuss therapeutic perspective.

Original languageEnglish
Pages (from-to)1150-1158
Number of pages9
JournalClinical Chemistry and Laboratory Medicine
Issue number9
Publication statusPublished - 2003 Oct 27
Externally publishedYes


  • Advanced glycosylation end-products
  • Carbonyl stress
  • Diabetes mellitus
  • Oxidative stress

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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