Carbonyl stress and diabetic complications

Toshio Miyata; Naoyoshi Ishikawa; Charles van Ypersele de Strihou

doi:10.1515/CCLM.2003.178

Carbonyl stress and diabetic complications

Toshio Miyata, Naoyoshi Ishikawa, Charles van Ypersele de Strihou

Research output: Contribution to journal › Review article › peer-review

39 Citations (Scopus)

Abstract

Advanced glycation irreversibly and progressively modifies proteins over time and yields the advanced glycation end-products (AGE). AGEs are thought to contribute to the development of atherosclerosis and of diabetic and uremic complications. Their inhibition has thus become a therapeutic goal. In this article, we discuss the role of various reactive carbonyl compound (RCOs) in the genesis of AGEs, postulate the existence of "carbonyl stress" in complicated diabetes and, finally, discuss therapeutic perspective.

Original language	English
Pages (from-to)	1150-1158
Number of pages	9
Journal	Clinical Chemistry and Laboratory Medicine
Volume	41
Issue number	9
DOIs	https://doi.org/10.1515/CCLM.2003.178
Publication status	Published - 2003 Oct 27
Externally published	Yes

Keywords

Advanced glycosylation end-products
Carbonyl stress
Diabetes mellitus
Oxidative stress

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1515/CCLM.2003.178

Cite this

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AU - Ishikawa, Naoyoshi

AU - van Ypersele de Strihou, Charles

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N2 - Advanced glycation irreversibly and progressively modifies proteins over time and yields the advanced glycation end-products (AGE). AGEs are thought to contribute to the development of atherosclerosis and of diabetic and uremic complications. Their inhibition has thus become a therapeutic goal. In this article, we discuss the role of various reactive carbonyl compound (RCOs) in the genesis of AGEs, postulate the existence of "carbonyl stress" in complicated diabetes and, finally, discuss therapeutic perspective.

AB - Advanced glycation irreversibly and progressively modifies proteins over time and yields the advanced glycation end-products (AGE). AGEs are thought to contribute to the development of atherosclerosis and of diabetic and uremic complications. Their inhibition has thus become a therapeutic goal. In this article, we discuss the role of various reactive carbonyl compound (RCOs) in the genesis of AGEs, postulate the existence of "carbonyl stress" in complicated diabetes and, finally, discuss therapeutic perspective.

KW - Advanced glycosylation end-products

KW - Carbonyl stress

KW - Diabetes mellitus

KW - Oxidative stress

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Carbonyl stress and diabetic complications

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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