TY - JOUR
T1 - Carboxyl‐terminal Heparin‐binding Fragments of Platelet Factor 4 Retain the Blocking Effect on the Receptor Binding of Basic Fibroblast Growth Factor
AU - Sato, Yasufumi
AU - Waki, Michinori
AU - Ohno, Motonori
AU - Kuwano, Michihiko
AU - Sakata, Toshiie
PY - 1993/5
Y1 - 1993/5
N2 - Platelet factor 4 (PF‐4) blocks the binding of basic fibroblast growth factor (bFGF) to its receptor. In the present study, we constructed carboxyl‐terminal fragments, which represent the heparin‐binding region of the PF‐4 molecule, and examined whether these synthetic peptides retain the blocking effects on the receptor binding of bFGF. Synthetic peptides inhibited the receptor binding of bFGF. Furthermore, they inhibited the migration and tube formation of bovine capillary endothelial cells in culture (these phenomena are dependent on endogenous bFGF).
AB - Platelet factor 4 (PF‐4) blocks the binding of basic fibroblast growth factor (bFGF) to its receptor. In the present study, we constructed carboxyl‐terminal fragments, which represent the heparin‐binding region of the PF‐4 molecule, and examined whether these synthetic peptides retain the blocking effects on the receptor binding of bFGF. Synthetic peptides inhibited the receptor binding of bFGF. Furthermore, they inhibited the migration and tube formation of bovine capillary endothelial cells in culture (these phenomena are dependent on endogenous bFGF).
KW - Basic fibroblast growth factor
KW - Heparin‐binding domain
KW - Platelet factor 4
KW - Receptor binding
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U2 - 10.1111/j.1349-7006.1993.tb00163.x
DO - 10.1111/j.1349-7006.1993.tb00163.x
M3 - Article
C2 - 8320164
AN - SCOPUS:0027322052
SN - 0910-5050
VL - 84
SP - 485
EP - 488
JO - Japanese Journal of Cancer Research
JF - Japanese Journal of Cancer Research
IS - 5
ER -
