Cardio-ankle vascular index in heterozygous familial hypercholesterolemia

Vladimir Soska, Petr Dobsak, Ladislav Dusek, Kohji Shirai, Jiri Jarkovsky, Marie Novakova, Petr Brhel, Jana Stastna, Lenka Fajkusova, Tomas Freiberger, Tomoyuki Yambe

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28 Citations (Scopus)


Aim: The cardio-ankle vascular index (CAVI) is a new non-invasive marker of arterial stiffness and atherosclerosis. The purpose of this study was to compare CAVI in patients with heterozygous familial hypercholesterolemia (FH) and in healthy controls. Methods: 82 FH subjects (27 males, 65 females), aged 53.7±13.6 years without clinical symptoms of cardiovascular diseases and 359 healthy controls (121 males, 238 females), aged 43.9±14.9 years, were examined. CAVI was measured using the system VaSera® 1500. Results: CAVI in FH patients was significantly higher (8.0 ± 1.4) than in healthy subjects (7.5± 1.3) p = 0.002; however, age, sex and BMI adjusted CAVI did not differ significantly (p = 0.061) between the FH group (7.5, CI: 7.3; 7.7) and control group (7.7, CI: 7.6; 7.7). Conclusion: The study showed no significant difference in CAVI between heterozygous FH and healthy controls.

Original languageEnglish
Pages (from-to)453-461
Number of pages9
JournalJournal of Atherosclerosis and Thrombosis
Issue number5
Publication statusPublished - 2012


  • Atherosclerosis
  • Cardio-ankle vascular index
  • Ezetimibe
  • Familial hypercholesterolemia
  • Statins


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