Carolacton (1) was isolated from the culture broth of Sorangium cellulosum strain So ce960 and possesses 12-membered macrocyclic lactone with an aliphatic chain bearing a carboxy group at terminal. It exhibits reduction of the number of viable cells in biofilms. In this review, total synthesis, truncated analog synthesis, and biological phenomenon of 1 are described.
|Number of pages||2|
|Journal||Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry|
|Publication status||Published - 2017|