Carotid web leads to new thrombus formation: computational fluid dynamic analysis coupled with histological evidence

Dan Ozaki; Toshiki Endo; Hiroyoshi Suzuki; Shin ichiro Sugiyama; Kaoru Endo; Ryo Itabashi; Miki Fujimura; Teiji Tominaga

doi:10.1007/s00701-020-04272-2

Carotid web leads to new thrombus formation: computational fluid dynamic analysis coupled with histological evidence

Dan Ozaki, Toshiki Endo, Hiroyoshi Suzuki, Shin ichiro Sugiyama, Kaoru Endo, Ryo Itabashi, Miki Fujimura, Teiji Tominaga

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15 Citations (Scopus)

Abstract

Carotid web has been recognized as a rare cause of ischemic stroke with high recurrence rate. We describe a 48-year-old woman with carotid web who developed embolic stroke. We obtained a fresh thrombus from the internal carotid artery when carotid endarterectomy was performed. A preoperative computational fluid dynamics (CFD) study showed stagnation of blood around the web structure as well as the low wall shear stress. The rheological analysis newly disclosed mechanisms of thrombus formation related to the carotid web. CFD study in the carotid web may determine indication and timing of surgical interventions with further accumulation of clinical evidence.

Original language	English
Pages (from-to)	2583-2588
Number of pages	6
Journal	Acta Neurochirurgica
Volume	162
Issue number	10
DOIs	https://doi.org/10.1007/s00701-020-04272-2
Publication status	Published - 2020 Oct 1

Keywords

Carotid endarterectomy
Carotid web
Computational fluid dynamics
Recurrent stroke

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10.1007/s00701-020-04272-2

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abstract = "Carotid web has been recognized as a rare cause of ischemic stroke with high recurrence rate. We describe a 48-year-old woman with carotid web who developed embolic stroke. We obtained a fresh thrombus from the internal carotid artery when carotid endarterectomy was performed. A preoperative computational fluid dynamics (CFD) study showed stagnation of blood around the web structure as well as the low wall shear stress. The rheological analysis newly disclosed mechanisms of thrombus formation related to the carotid web. CFD study in the carotid web may determine indication and timing of surgical interventions with further accumulation of clinical evidence.",

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T2 - computational fluid dynamic analysis coupled with histological evidence

AU - Ozaki, Dan

AU - Endo, Toshiki

AU - Suzuki, Hiroyoshi

AU - Sugiyama, Shin ichiro

AU - Endo, Kaoru

AU - Itabashi, Ryo

AU - Fujimura, Miki

AU - Tominaga, Teiji

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AB - Carotid web has been recognized as a rare cause of ischemic stroke with high recurrence rate. We describe a 48-year-old woman with carotid web who developed embolic stroke. We obtained a fresh thrombus from the internal carotid artery when carotid endarterectomy was performed. A preoperative computational fluid dynamics (CFD) study showed stagnation of blood around the web structure as well as the low wall shear stress. The rheological analysis newly disclosed mechanisms of thrombus formation related to the carotid web. CFD study in the carotid web may determine indication and timing of surgical interventions with further accumulation of clinical evidence.

KW - Carotid endarterectomy

KW - Carotid web

KW - Computational fluid dynamics

KW - Recurrent stroke

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Carotid web leads to new thrombus formation: computational fluid dynamic analysis coupled with histological evidence

Abstract

Keywords

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