@article{e51ca36df14a4bd9872e9b61826e7878,
title = "Catalytic Alkynylation of Polyfluoroarenes by Amide Base Generated In Situ",
abstract = "We herein demonstrate that the amide base generated in situ from CsF and N(TMS)3 catalyzes the deprotonative coupling reactions of terminal alkynes with polyfluoroarenes, wherein mono- and dialkynylations occur efficiently for penta- and hexafluorobenzenes, respectively. Tetraalkynylated products could also be synthesized from dialkynylated compounds.",
keywords = "alkynes, amide base, aromatic substitution, C−C coupling, polyfluoroarenes",
author = "Masanori Shigeno and Takuya Okawa and Masaya Imamatsu and Kanako Nozawa-Kumada and Yoshinori Kondo",
note = "Funding Information: This work was financially supported by JSPS KAKENHI Grant Number 16H00997 in Precisely Designed Catalysts with Customized Scaffolding (Y.K.), JSPS KAKENHI Grant Number 19H03346 (Y.K.), JSPS KAKENHI Grant Number 17K15419 (M.S.), Grand for Basic Science Research Projects from The Sumitomo Foundation (M.S.), Yamaguchi Educational and Scholarship Foundation (M.S.), and also the Platform Project for Supporting Drug Discovery and Life Science Research funded by Japan Agency for Medical Research and Development (AMED) (M.S., K.N.K., and Y.K.). Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = aug,
day = "6",
doi = "10.1002/chem.201901501",
language = "English",
volume = "25",
pages = "10294--10297",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "44",
}