TY - JOUR
T1 - Causes of cancer death among first-degree relatives in Japanese families with lynch syndrome
AU - Tanakaya, Kohji
AU - Yamaguchi, Tatsuro
AU - Ishikawa, Hideki
AU - Hinoi, Takao
AU - Furukawa, Yoichi
AU - Hirata, Keiji
AU - Saida, Yoshihisa
AU - Shimokawa, Mototsugu
AU - Arai, Masami
AU - Matsubara, Nagahide
AU - Tomita, Naohiro
AU - Tamura, Kazuo
AU - Sugano, Kokichi
AU - Ishioka, Chikashi
AU - Yoshida, Teruhiko
AU - Ishida, Hideyuki
AU - Watanabe, Toshiaki
AU - Sugihara, Kenichi
PY - 2016/4
Y1 - 2016/4
N2 - Aim: To elucidate the causes of cancer death in Japanese families with Lynch syndrome (LS). Methods: The distributions of cancer deaths in 485 individuals from 67 families with LS (35, 30, and two families with MutL homologue 1 (MLH1), MSH2, and MSH6 gene mutations, respectively), obtained from the Registry of the Japanese Society for Cancer of the Colon and Rectum were analyzed. Results: Among 98 cancer deaths of first-degree relatives of unknown mutation status, 53%, 19%, 13% (among females), 7% (among females) and 5% were due to colorectal, gastric, uterine, ovarian, and hepatobiliary cancer, respectively. The proportion of deaths from extra-colonic cancer was significantly higher in families with MSH2 mutation than in those with MLH1 mutation (p=0.003). Conclusion: In addition to colonic and uterine cancer, management and surveillance targeting gastric, ovarian and hepatobiliary cancer are considered important for Japanese families with LS. Extra-colonic cancer in families with MSH2 mutation might require for more intensive surveillance.
AB - Aim: To elucidate the causes of cancer death in Japanese families with Lynch syndrome (LS). Methods: The distributions of cancer deaths in 485 individuals from 67 families with LS (35, 30, and two families with MutL homologue 1 (MLH1), MSH2, and MSH6 gene mutations, respectively), obtained from the Registry of the Japanese Society for Cancer of the Colon and Rectum were analyzed. Results: Among 98 cancer deaths of first-degree relatives of unknown mutation status, 53%, 19%, 13% (among females), 7% (among females) and 5% were due to colorectal, gastric, uterine, ovarian, and hepatobiliary cancer, respectively. The proportion of deaths from extra-colonic cancer was significantly higher in families with MSH2 mutation than in those with MLH1 mutation (p=0.003). Conclusion: In addition to colonic and uterine cancer, management and surveillance targeting gastric, ovarian and hepatobiliary cancer are considered important for Japanese families with LS. Extra-colonic cancer in families with MSH2 mutation might require for more intensive surveillance.
KW - Causes of cancer deaths
KW - First-degree relative
KW - Japan
KW - Lynch syndrome
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M3 - Article
C2 - 27069191
AN - SCOPUS:84984538932
SN - 0250-7005
VL - 36
SP - 1985
EP - 1989
JO - Anticancer Research
JF - Anticancer Research
IS - 4
ER -
