cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein

Nishimura Hitoshi Nishimura; Kakizaki Ikuko Kakizaki; Muta Tatsushi Muta; Sasaki Nobumi Sasaki; Xiao Pu Ping Xiao Pu; Yamashita Toshiyuki Yamashita; Nagasawa Shigeharu Nagasawa

doi:10.1016/0014-5793(94)01364-7

cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein

Nishimura Hitoshi Nishimura, Kakizaki Ikuko Kakizaki, Muta Tatsushi Muta, Sasaki Nobumi Sasaki, Xiao Pu Ping Xiao Pu, Yamashita Toshiyuki Yamashita, Nagasawa Shigeharu Nagasawa

Research output: Contribution to journal › Article › peer-review

79 Citations (Scopus)

Abstract

PK-120 is a substrate for plasma kallikrein (PK), recently purified from human plasma. Here we have established the cDNA sequence for human PK-120 mRNA. The deduced amino sequence of PK-120 revealed that it consists of 902 amino acid residues with a calculated mass of 116,423 Da. The putative cleavage sites by PK have been proposed, suggesting that PK-120 may be a precursor of a bioactive peptide. Most interestingly, PK-120 showed significant sequence identities to heavy chains (HCs) of the inter-α-trypsin inhibitor (ITI) superfamily.

Original language	English
Pages (from-to)	207-211
Number of pages	5
Journal	FEBS Letters
Volume	357
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(94)01364-7
Publication status	Published - 1995 Jan 3
Externally published	Yes

Keywords

Bradykinin
Human
Hyaluronic acid
Inter-α-trypsin inhibitor
Plasma glycoprotein
Plasma kallikrein
cDNA cloning

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(94)01364-7

Cite this

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title = "cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein",

abstract = "PK-120 is a substrate for plasma kallikrein (PK), recently purified from human plasma. Here we have established the cDNA sequence for human PK-120 mRNA. The deduced amino sequence of PK-120 revealed that it consists of 902 amino acid residues with a calculated mass of 116,423 Da. The putative cleavage sites by PK have been proposed, suggesting that PK-120 may be a precursor of a bioactive peptide. Most interestingly, PK-120 showed significant sequence identities to heavy chains (HCs) of the inter-α-trypsin inhibitor (ITI) superfamily.",

keywords = "Bradykinin, Human, Hyaluronic acid, Inter-α-trypsin inhibitor, Plasma glycoprotein, Plasma kallikrein, cDNA cloning",

author = "{Hitoshi Nishimura}, Nishimura and {Ikuko Kakizaki}, Kakizaki and {Tatsushi Muta}, Muta and {Nobumi Sasaki}, Sasaki and {Ping Xiao Pu}, {Xiao Pu} and {Toshiyuki Yamashita}, Yamashita and {Shigeharu Nagasawa}, Nagasawa",

year = "1995",

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doi = "10.1016/0014-5793(94)01364-7",

language = "English",

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journal = "FEBS Letters",

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T1 - cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein

AU - Hitoshi Nishimura, Nishimura

AU - Ikuko Kakizaki, Kakizaki

AU - Tatsushi Muta, Muta

AU - Nobumi Sasaki, Sasaki

AU - Ping Xiao Pu, Xiao Pu

AU - Toshiyuki Yamashita, Yamashita

AU - Shigeharu Nagasawa, Nagasawa

PY - 1995/1/3

Y1 - 1995/1/3

N2 - PK-120 is a substrate for plasma kallikrein (PK), recently purified from human plasma. Here we have established the cDNA sequence for human PK-120 mRNA. The deduced amino sequence of PK-120 revealed that it consists of 902 amino acid residues with a calculated mass of 116,423 Da. The putative cleavage sites by PK have been proposed, suggesting that PK-120 may be a precursor of a bioactive peptide. Most interestingly, PK-120 showed significant sequence identities to heavy chains (HCs) of the inter-α-trypsin inhibitor (ITI) superfamily.

AB - PK-120 is a substrate for plasma kallikrein (PK), recently purified from human plasma. Here we have established the cDNA sequence for human PK-120 mRNA. The deduced amino sequence of PK-120 revealed that it consists of 902 amino acid residues with a calculated mass of 116,423 Da. The putative cleavage sites by PK have been proposed, suggesting that PK-120 may be a precursor of a bioactive peptide. Most interestingly, PK-120 showed significant sequence identities to heavy chains (HCs) of the inter-α-trypsin inhibitor (ITI) superfamily.

KW - Bradykinin

KW - Human

KW - Hyaluronic acid

KW - Inter-α-trypsin inhibitor

KW - Plasma glycoprotein

KW - Plasma kallikrein

KW - cDNA cloning

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cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein

Abstract

Keywords

ASJC Scopus subject areas

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