Cell-driven three-dimensional manipulation of microparts for a microassembly

Takayuki Hoshino, Ayako Higashi, Tomohiro Konno, Kazuhiko Ishihara, Keisuke Morishima

Research output: Contribution to journalArticlepeer-review


Biological motility consisting of cell migration can be embedded in nano- and micro-mechanical systems. We have focused on the actin polymerization to employ its generative force as the driving force of a nano mechanical system. Cells are a self-sustaining full system which contains an energy supply and has self-organization of actin filaments. This self-organized driving force powered by the cells should be utilizable in a functionally designed nano or micro mechanical assembly. This paper describes locomotion of micro-parts driven by cell migration. A method to generate three-dimensional (3D) cell-driven operation of the micro-parts was investigated for a micro-assembly using two-dimensional (2D) cell-adhesive patterning of a substrate. Cyclic reattachment of cell membranes occurred on a discrete cell-adhesive portion within a 100-μm-pitch checkerboard pattern during cell migration. These movements of cells modulated the 2D cell migration to a 3D tilting movement of the micro-partson- cells and 180-mm-length micro-parts were successfully flipped by the cell migration power.

Original languageEnglish
Pages (from-to)06GM031-06GM034
JournalJapanese Journal of Applied Physics
Issue number6 PART 2
Publication statusPublished - 2010 Jun


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