TY - JOUR
T1 - Cellular uptake behavior of fluorescein
T2 - Intercalated layered double hydroxide
AU - Tanaka, Miyuki
AU - Aisawa, Sumio
AU - Hirahara, Hidetoshi
AU - Narita, Eiichi
AU - Yin, Shu
AU - Sato, Tsugio
PY - 2012/6
Y1 - 2012/6
N2 - In order to define the ability of layered double hydroxide (LDH) as materials for drug delivery, fluorescein (Fluo) anion intercalated LDH (Fluo/LDH) was synthesized by hydrothermal treatment and observed the cellular uptake of the Fluo/LDH for mammalian cell (L929). The synthesized Fluo/LDH showed a LDH structure, high fluorescence and low cytotoxicity. According to the fluorescence, confocal and TEM images of cells, the Fluo/LDH seemed to be internalized into the L929 cell by cellular endocytosis and dissolved inside the cell to exhibit the fluorescence of cellular cytoplasm.
AB - In order to define the ability of layered double hydroxide (LDH) as materials for drug delivery, fluorescein (Fluo) anion intercalated LDH (Fluo/LDH) was synthesized by hydrothermal treatment and observed the cellular uptake of the Fluo/LDH for mammalian cell (L929). The synthesized Fluo/LDH showed a LDH structure, high fluorescence and low cytotoxicity. According to the fluorescence, confocal and TEM images of cells, the Fluo/LDH seemed to be internalized into the L929 cell by cellular endocytosis and dissolved inside the cell to exhibit the fluorescence of cellular cytoplasm.
KW - cellular uptake
KW - fluorescein
KW - Layered double hydroxide
UR - http://www.scopus.com/inward/record.url?scp=84862187708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862187708&partnerID=8YFLogxK
U2 - 10.1142/S179360471260003X
DO - 10.1142/S179360471260003X
M3 - Article
AN - SCOPUS:84862187708
SN - 1793-6047
VL - 5
JO - Functional Materials Letters
JF - Functional Materials Letters
IS - 2
M1 - 1260003
ER -