Cerebral circulation in aging

Ken Nagata, Takashi Yamazaki, Daiki Takano, Tetsuya Maeda, Yumi Fujimaki, Taizen Nakase, Yuichi Sato

Research output: Contribution to journalReview articlepeer-review

60 Citations (Scopus)


Cerebral circulation is known to be protected by the regulatory function against the hypoperfusion that will affect the cognitive function as a result of brain ischemia and energy failure. The regulatory function includes cerebrovascular autoregulation, chemical control, metabolic control, and neurogenic control, and those compensatory mechanisms can be influenced by hypertension, atherosclerosis, cardiac diseases, cerebrovascular diseases and aging. On the other hand, large and/or small infarction, intracranial hemorrhage, subarachnoid hemorrhage, atherosclerosis, amylod angiopathy are also more directly associated with cognitive decline not only in those with vascular cognitive impairment or vascular dementia but also those with Alzheimer's disease.

Original languageEnglish
Pages (from-to)49-60
Number of pages12
JournalAgeing Research Reviews
Publication statusPublished - 2016 Sept 1


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