Cerebral glucose utilization in pediatric neurological disorders determined by positron emission tomography

Kazuhiko Yanai, Kazuie Iinuma, Taiju Matsuzawa, Masatoshi Ito, Shigeaki Miyabayashi, Kuniaki Narisawa, Tatsuo Ido, Kenji Yamada, Keiya Tada

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


We measured local cerebral glucose utilization in 19 patients with Lennox-Gastaut syndrome (LG), partial seizures (PS), atypical and classical phenylketonuria (PKU), Leigh disease, and subacute sclerosing panencephalitis (SSPE), using positron emission tomography (PET). The mean values of regional glucose utilization in interictal scans of LG were significantly reduced in all brain regions when compared with that of PS (P<0.005). PET studies of glucose utilization in LG revealed more widespread hypometabolism than in PS. Two siblings with dihydropteridine reductase deficiency, a patient with classical PKU, and a boy with cytochrome c oxidase deficiency showed reduced glucose utilization in the caudate and putamen. A marked decrease in glucose utilization was found in the cortical gray matter of a patient with rapidly progressive SSPE, despite relatively preserved utilization in the caudate and putamen. The PET study of a patient with slowly progressive SSPE revealed patterns and values of glucose utilization similar to those of the control. Thus, PET provided a useful clue toward understanding brain dysfunction in LG, PS, PKU, Leigh disease, and SSPE.

Original languageEnglish
Pages (from-to)292-296
Number of pages5
JournalEuropean Journal of Nuclear Medicine
Issue number6
Publication statusPublished - 1987 Sept


  • Epilepsy
  • Leigh disease
  • Phenylketonuria
  • Positron emission tomography
  • Subacute sclerosing panencephalitis


Dive into the research topics of 'Cerebral glucose utilization in pediatric neurological disorders determined by positron emission tomography'. Together they form a unique fingerprint.

Cite this