TY - JOUR
T1 - Cerebrospinal fluid aquaporin-4 antibody levels in neuromyelitis optica attacks
AU - Sato, Douglas Kazutoshi
AU - Callegaro, Dagoberto
AU - De Haidar Jorge, Frederico M.
AU - Nakashima, Ichiro
AU - Nishiyama, Shuhei
AU - Takahashi, Toshiyuki
AU - Simm, Renata Faria
AU - Apostolos-Pereira, Samira Luisa
AU - Misu, Tatsuro
AU - Steinman, Lawrence
AU - Aoki, Masashi
AU - Fujihara, Kazuo
PY - 2014/8
Y1 - 2014/8
N2 - To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The CSF aquaporin-4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin-6 that can regulate antibody-producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin-4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks.
AB - To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The CSF aquaporin-4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin-6 that can regulate antibody-producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin-4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks.
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U2 - 10.1002/ana.24208
DO - 10.1002/ana.24208
M3 - Article
C2 - 24977390
AN - SCOPUS:84907597533
SN - 0364-5134
VL - 76
SP - 305
EP - 309
JO - Annals of Neurology
JF - Annals of Neurology
IS - 2
ER -