Cerebrospinal fluid aquaporin-4 antibody levels in neuromyelitis optica attacks

Douglas Kazutoshi Sato, Dagoberto Callegaro, Frederico M. De Haidar Jorge, Ichiro Nakashima, Shuhei Nishiyama, Toshiyuki Takahashi, Renata Faria Simm, Samira Luisa Apostolos-Pereira, Tatsuro Misu, Lawrence Steinman, Masashi Aoki, Kazuo Fujihara

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The CSF aquaporin-4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin-6 that can regulate antibody-producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin-4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalAnnals of Neurology
Issue number2
Publication statusPublished - 2014 Aug

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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