Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathology

Hiroyuki Arai; Yu ichi Morikawa; Makoto Higuchi; Toshifumi Matsui; Christopher M. Clark; Masakazu Miura; Nobuo Machida; Virginia M.Y. Lee; John Q. Trojanowski; Hidetada Sasaki

doi:10.1006/bbrc.1997.6908

Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathology

Hiroyuki Arai, Yu ichi Morikawa, Makoto Higuchi, Toshifumi Matsui, Christopher M. Clark, Masakazu Miura, Nobuo Machida, Virginia M.Y. Lee, John Q. Trojanowski, Hidetada Sasaki

Research output: Contribution to journal › Article › peer-review

139 Citations (Scopus)

Abstract

Cerebrospinal fluid tau (CSF-tau) levels were quantified in 8 patients with frontotemporal dementia (FTD), 6 patients with progressive supranuclear palsy (PSP), 3 patients with corticobasal degeneration (CBD), and 6 patients with dementia with Lewy bodies (DLB). The CSF-tau levels were significantly increased in FTD and DLB, but not in PSP and CBD, compared to that previously reported in normal controls. Notably, the CSF-tau level in DLB was as high as that in Alzheimer's disease (AD). Our study suggests that tau may accumulate in the CSF of patients with certain neurodegenerative diseases other than AD and that measurement of CSF-tau may not distinguish AD from DLB.

Original language	English
Pages (from-to)	262-264
Number of pages	3
Journal	Biochemical and biophysical research communications
Volume	236
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1997.6908
Publication status	Published - 1997 Jul 18
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.1997.6908

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abstract = "Cerebrospinal fluid tau (CSF-tau) levels were quantified in 8 patients with frontotemporal dementia (FTD), 6 patients with progressive supranuclear palsy (PSP), 3 patients with corticobasal degeneration (CBD), and 6 patients with dementia with Lewy bodies (DLB). The CSF-tau levels were significantly increased in FTD and DLB, but not in PSP and CBD, compared to that previously reported in normal controls. Notably, the CSF-tau level in DLB was as high as that in Alzheimer's disease (AD). Our study suggests that tau may accumulate in the CSF of patients with certain neurodegenerative diseases other than AD and that measurement of CSF-tau may not distinguish AD from DLB.",

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AU - Arai, Hiroyuki

AU - Morikawa, Yu ichi

AU - Higuchi, Makoto

AU - Matsui, Toshifumi

AU - Clark, Christopher M.

AU - Miura, Masakazu

AU - Machida, Nobuo

AU - Lee, Virginia M.Y.

AU - Trojanowski, John Q.

AU - Sasaki, Hidetada

PY - 1997/7/18

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AB - Cerebrospinal fluid tau (CSF-tau) levels were quantified in 8 patients with frontotemporal dementia (FTD), 6 patients with progressive supranuclear palsy (PSP), 3 patients with corticobasal degeneration (CBD), and 6 patients with dementia with Lewy bodies (DLB). The CSF-tau levels were significantly increased in FTD and DLB, but not in PSP and CBD, compared to that previously reported in normal controls. Notably, the CSF-tau level in DLB was as high as that in Alzheimer's disease (AD). Our study suggests that tau may accumulate in the CSF of patients with certain neurodegenerative diseases other than AD and that measurement of CSF-tau may not distinguish AD from DLB.

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Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathology

Abstract

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