CGRP in peripherally axotomized mesencephalic trigeminal neurones of the rat

Akihiro Yoshida; Hiroyuki Ichikawa; Tomosada Sugimoto

doi:10.1097/00001756-199504190-00003

CGRP in peripherally axotomized mesencephalic trigeminal neurones of the rat

Akihiro Yoshida, Hiroyuki Ichikawa, Tomosada Sugimoto

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Immunoreactivities for substance P (SP-ir) and calcitonin gene-related peptide (CGRP-ir) were examined in neurones in the mesencephalic trigeminal tract nucleus of nerve-injured rats. One week following unilateral transection of the trigeminal root, the masseteric nerve (MN) or the inferior alveolar nerve (IAN), CGRP-ir but not SP-ir was detected in these neurones bilaterally with ipsilateral dominance. Most of the CGRP-ir (immunoreactive) neurones were retrogradely labelled when fluorogold (FG) had been applied to the proximal stump of the MN or the IAN. Sham surgery including insult to the masseter muscle induced CGRP-ir while skin incision did not.

Original language	English
Pages (from-to)	837-840
Number of pages	4
Journal	NeuroReport
Volume	6
Issue number	6
DOIs	https://doi.org/10.1097/00001756-199504190-00003
Publication status	Published - 1995 Apr
Externally published	Yes

Keywords

Calcitonin gene-related peptide
Inferior alveolar nerve
Masseteric nerve
Mesencephalic trigeminal tract nucleus
Peripheral axotomy
Trigeminal nerve root

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-199504190-00003

Cite this

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title = "CGRP in peripherally axotomized mesencephalic trigeminal neurones of the rat",

abstract = "Immunoreactivities for substance P (SP-ir) and calcitonin gene-related peptide (CGRP-ir) were examined in neurones in the mesencephalic trigeminal tract nucleus of nerve-injured rats. One week following unilateral transection of the trigeminal root, the masseteric nerve (MN) or the inferior alveolar nerve (IAN), CGRP-ir but not SP-ir was detected in these neurones bilaterally with ipsilateral dominance. Most of the CGRP-ir (immunoreactive) neurones were retrogradely labelled when fluorogold (FG) had been applied to the proximal stump of the MN or the IAN. Sham surgery including insult to the masseter muscle induced CGRP-ir while skin incision did not.",

keywords = "Calcitonin gene-related peptide, Inferior alveolar nerve, Masseteric nerve, Mesencephalic trigeminal tract nucleus, Peripheral axotomy, Trigeminal nerve root",

author = "Akihiro Yoshida and Hiroyuki Ichikawa and Tomosada Sugimoto",

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TY - JOUR

T1 - CGRP in peripherally axotomized mesencephalic trigeminal neurones of the rat

AU - Yoshida, Akihiro

AU - Ichikawa, Hiroyuki

AU - Sugimoto, Tomosada

PY - 1995/4

Y1 - 1995/4

N2 - Immunoreactivities for substance P (SP-ir) and calcitonin gene-related peptide (CGRP-ir) were examined in neurones in the mesencephalic trigeminal tract nucleus of nerve-injured rats. One week following unilateral transection of the trigeminal root, the masseteric nerve (MN) or the inferior alveolar nerve (IAN), CGRP-ir but not SP-ir was detected in these neurones bilaterally with ipsilateral dominance. Most of the CGRP-ir (immunoreactive) neurones were retrogradely labelled when fluorogold (FG) had been applied to the proximal stump of the MN or the IAN. Sham surgery including insult to the masseter muscle induced CGRP-ir while skin incision did not.

AB - Immunoreactivities for substance P (SP-ir) and calcitonin gene-related peptide (CGRP-ir) were examined in neurones in the mesencephalic trigeminal tract nucleus of nerve-injured rats. One week following unilateral transection of the trigeminal root, the masseteric nerve (MN) or the inferior alveolar nerve (IAN), CGRP-ir but not SP-ir was detected in these neurones bilaterally with ipsilateral dominance. Most of the CGRP-ir (immunoreactive) neurones were retrogradely labelled when fluorogold (FG) had been applied to the proximal stump of the MN or the IAN. Sham surgery including insult to the masseter muscle induced CGRP-ir while skin incision did not.

KW - Calcitonin gene-related peptide

KW - Inferior alveolar nerve

KW - Masseteric nerve

KW - Mesencephalic trigeminal tract nucleus

KW - Peripheral axotomy

KW - Trigeminal nerve root

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CGRP in peripherally axotomized mesencephalic trigeminal neurones of the rat

Abstract

Keywords

ASJC Scopus subject areas

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