CGRP in peripherally axotomized mesencephalic trigeminal neurones of the rat

Akihiro Yoshida, Hiroyuki Ichikawa, Tomosada Sugimoto

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Immunoreactivities for substance P (SP-ir) and calcitonin gene-related peptide (CGRP-ir) were examined in neurones in the mesencephalic trigeminal tract nucleus of nerve-injured rats. One week following unilateral transection of the trigeminal root, the masseteric nerve (MN) or the inferior alveolar nerve (IAN), CGRP-ir but not SP-ir was detected in these neurones bilaterally with ipsilateral dominance. Most of the CGRP-ir (immunoreactive) neurones were retrogradely labelled when fluorogold (FG) had been applied to the proximal stump of the MN or the IAN. Sham surgery including insult to the masseter muscle induced CGRP-ir while skin incision did not.

Original languageEnglish
Pages (from-to)837-840
Number of pages4
Issue number6
Publication statusPublished - 1995 Apr
Externally publishedYes


  • Calcitonin gene-related peptide
  • Inferior alveolar nerve
  • Masseteric nerve
  • Mesencephalic trigeminal tract nucleus
  • Peripheral axotomy
  • Trigeminal nerve root

ASJC Scopus subject areas

  • Neuroscience(all)


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