Challenges in biocatalysis: immobilization of pepsin in mesoporous silicates

Haresh G. Manyar, Simonetta Tumbiolo, Enrica Gianotti, Yasuhiro Sakamoto, Osamu Terasaki, Salvatore Coluccia

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


A facile preparation of Silico-Pepsin biocatalysts within mesoporous silicas, MCM-41 and SBA-15 has been achieved, by encapsulation of the enzyme. The shrinking of the pores was obtained by grafting with 3-aminopropyltriethoxysilane (APTES). The hybrid bio-inorganic materials were characterized by XRD, TEM, Volumetric (N2 sorption), FT-IR and DR-UV-Vis techniques and their catalytic activity was evaluated by peptic hydrolysis of a dipeptide, Z-L-glutamyl-L-tyrosine solution.

Original languageEnglish
Title of host publicationZeolites and related materials
Subtitle of host publicationTrends, targets and challenges
Number of pages4
Publication statusPublished - 2008
Externally publishedYes

Publication series

NameStudies in Surface Science and Catalysis
ISSN (Print)0167-2991


  • MCM-41
  • Pepsin
  • SBA-15
  • biocatalysts
  • enzyme immobilization
  • hybrid bio-inorganic materials
  • mesoporous silicates

ASJC Scopus subject areas

  • Catalysis
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry


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