Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury

Metabolomic analysis was performed using the cerebellum of methylmercury-treated mice to elucidate the molecular mechanisms underlying methylmercury-induced cerebellar dysfunction. Methylmercury administration led to significant increases in the levels of 11 low molecular weight metab-olites and significant reductions in the levels of 29 others, including several metabolites produced by ami-no acid and purine metabolism. Non-significant decreases in metabolites involved in the TCA cycle and in glutathione metabolism were also observed. in glutathione metabolism were also observed.