TY - JOUR
T1 - Characteristic correlations of the structure-function relationship in different glaucomatous disc types
AU - Omodaka, Kazuko
AU - Takada, Naoko
AU - Yamaguchi, Takuhiro
AU - Takahashi, Hidetoshi
AU - Araie, Makoto
AU - Nakazawa, Toru
N1 - Funding Information:
The authors thank Drs. Yukihiro Shiga, Yu Yokoyama, and Satoru Tsuda for collecting the patient data used in this study and Mr. Tim Hilts for editing the manuscript. This study was supported in part by a JST grant from JSPS KAKENHI Grants-in-Aid for Scientific Research (B) (T.N., 26293372) and for Exploratory Research (T.N., 26670751) and by the JST Center for Revitalization Promotion.
Publisher Copyright:
© 2015, Japanese Ophthalmological Society.
PY - 2015/7/23
Y1 - 2015/7/23
N2 - Purpose: To investigate the influence of the optic disc type on the overall and regional correlation between structure and function in open angle glaucoma (OAG). Methods: We divided 144 eyes of 144 patients with OAG into four groups according to Nicolela et al.’s classification of optic disc type: focal ischemic (FI), myopic glaucomatous (MY), senile sclerotic (SS), and generalized enlargement (GE). We measured the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) with the 3D OCT-2000 and the mean deviation (MD) with the Humphrey Field Analyzer in each group and determined the influence of the disc type on these parameters with the Spearman rank correlation. Results: We found that cpRNFLT and MD were significantly correlated in the MY (r = 0.61, P < 0.001), GE (r = 0.62, P < 0.001), and SS groups (r = 0.52, P = 0.002), but not in the FI group (r = 0.25, P = 0.130). The region of the optic disc with the highest correlation coefficient between structure and function differed according to the disc type. Conclusions: The correlation between cpRNFLT and MD varied according to the optic disc morphology in OAG. This suggests that different disc types have characteristic regional variations in the correlation between structure and function. The disc type should therefore be considered in investigations of the correlation between structure and function in glaucoma.
AB - Purpose: To investigate the influence of the optic disc type on the overall and regional correlation between structure and function in open angle glaucoma (OAG). Methods: We divided 144 eyes of 144 patients with OAG into four groups according to Nicolela et al.’s classification of optic disc type: focal ischemic (FI), myopic glaucomatous (MY), senile sclerotic (SS), and generalized enlargement (GE). We measured the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) with the 3D OCT-2000 and the mean deviation (MD) with the Humphrey Field Analyzer in each group and determined the influence of the disc type on these parameters with the Spearman rank correlation. Results: We found that cpRNFLT and MD were significantly correlated in the MY (r = 0.61, P < 0.001), GE (r = 0.62, P < 0.001), and SS groups (r = 0.52, P = 0.002), but not in the FI group (r = 0.25, P = 0.130). The region of the optic disc with the highest correlation coefficient between structure and function differed according to the disc type. Conclusions: The correlation between cpRNFLT and MD varied according to the optic disc morphology in OAG. This suggests that different disc types have characteristic regional variations in the correlation between structure and function. The disc type should therefore be considered in investigations of the correlation between structure and function in glaucoma.
KW - Axonal damage
KW - Glaucoma stage
KW - Open angle glaucoma
KW - Optic disc type
KW - Optical coherence tomography
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U2 - 10.1007/s10384-015-0379-z
DO - 10.1007/s10384-015-0379-z
M3 - Article
C2 - 25860862
AN - SCOPUS:84937394321
SN - 0021-5155
VL - 59
SP - 223
EP - 229
JO - Japanese Journal of Ophthalmology
JF - Japanese Journal of Ophthalmology
IS - 4
ER -