TY - JOUR
T1 - Characteristic effect of wall elasticity on flow instability and wall shear stress of a full-scale, patient-specific aneurysm model in the middle cerebral artery
T2 - An experimental approach
AU - Yamaguchi, Ryuhei
AU - Tanaka, Gaku
AU - Shafii, Nadia Shaira
AU - Osman, Kahar
AU - Shimizu, Yasutomo
AU - Saqr, Khalid M.
AU - Ohta, Makoto
N1 - Funding Information:
We acknowledge the contribution and support of the Ministry of Education Malaysia and Research Management Centre, Universiti Teknologi Malaysia. We also thank Dr. Teruaki Ikeda of TERAL Inc. and Dr. Takashi Fujiwara of Chiba University, who supported the construction of the aneurysm model from the anatomical. We also thank Enago proofreading Com (https://www.editage.jp) for editing a draft of this manuscript. Although we used morphology of cerebral aneurysm, we presented this morphology in our previous presentation. No animal studies were performed by the authors for this article. The present work was mainly supported by JSPS Science Research Budget #19K04163 and JPJSBP Bilateral Collaborating Research #120199910.
Publisher Copyright:
© 2022 Author(s).
PY - 2022/5/14
Y1 - 2022/5/14
N2 - The mechanisms underlying the growth and rupture of aneurysms are poorly understood. Although the wall shear stress (WSS) in elastic aneurysm models is examined using fluid-structure interaction (FSI) simulations, it has not been sufficiently validated using experimental modalities, such as particle image velocimetry (PIV) or phase contrast magnetic resonance imaging (PC-MRI). In this study, we investigated pulsatile flow in an elastic, image-based, patient-specific cerebral aneurysm model using PIV. The phantom model was carefully fabricated using a specialized technique by silicone elastomer. We explored the hemodynamics of the WSS and the kinetic energy cascade (KEC) in the elastic model compared with a rigid model, at the apex of the bifurcation of the middle cerebral artery (MCA) in vitro. The effects of elasticity on the WSS, WSS gradient (WSSG), and tensile strength of the aneurysm wall were also investigated, in addition to the effect of wall elasticity on the KEC compared to a rigid wall. Although the WSSG around the stagnation point had a large positive value, there was no difference between the two models. In particular, wall elasticity suppressed the WSS magnitude around the stagnation point and attenuated the KEC (i.e., the flow fluctuation). Future studies examining KEC frequency and WSS characteristics in a phantom model should consider assessing elasticity.
AB - The mechanisms underlying the growth and rupture of aneurysms are poorly understood. Although the wall shear stress (WSS) in elastic aneurysm models is examined using fluid-structure interaction (FSI) simulations, it has not been sufficiently validated using experimental modalities, such as particle image velocimetry (PIV) or phase contrast magnetic resonance imaging (PC-MRI). In this study, we investigated pulsatile flow in an elastic, image-based, patient-specific cerebral aneurysm model using PIV. The phantom model was carefully fabricated using a specialized technique by silicone elastomer. We explored the hemodynamics of the WSS and the kinetic energy cascade (KEC) in the elastic model compared with a rigid model, at the apex of the bifurcation of the middle cerebral artery (MCA) in vitro. The effects of elasticity on the WSS, WSS gradient (WSSG), and tensile strength of the aneurysm wall were also investigated, in addition to the effect of wall elasticity on the KEC compared to a rigid wall. Although the WSSG around the stagnation point had a large positive value, there was no difference between the two models. In particular, wall elasticity suppressed the WSS magnitude around the stagnation point and attenuated the KEC (i.e., the flow fluctuation). Future studies examining KEC frequency and WSS characteristics in a phantom model should consider assessing elasticity.
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U2 - 10.1063/5.0085417
DO - 10.1063/5.0085417
M3 - Article
AN - SCOPUS:85130286764
SN - 0021-8979
VL - 131
JO - Journal of Applied Physics
JF - Journal of Applied Physics
IS - 18
M1 - 184701
ER -