Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines

C. Sun; T. Yamato; Toru Furukawa; Y. Ohnishi; H. Kijima; Akira Horii

doi:10.3892/or.8.1.89

Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines

C. Sun, T. Yamato, Toru Furukawa, Y. Ohnishi, H. Kijima, Akira Horii

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Human pancreatic cancer is one of the most malignant diseases in the world. In order to save patients with pancreatic cancer, it is necessary to develop novel methods for treatment. For such a purpose, a series of well-characterized cancer cell lines are of great help for in vitro studies that are generally the first step in approaching the invention of novel methods for treatment. In the present study, we analyzed 15 human pancreatic cancer cell lines for genetic alterations of the K-ras, p53, p16, and SMAD4 genes, which are very frequent targets for mutation in pancreatic cancer; these cell lines are useful resources in cancer research.

Original language	English
Pages (from-to)	89-92
Number of pages	4
Journal	Oncology reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.3892/or.8.1.89
Publication status	Published - 2001

Keywords

K-ras
P16
P53
Pancreatic cancer
SMAD4

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/or.8.1.89

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abstract = "Human pancreatic cancer is one of the most malignant diseases in the world. In order to save patients with pancreatic cancer, it is necessary to develop novel methods for treatment. For such a purpose, a series of well-characterized cancer cell lines are of great help for in vitro studies that are generally the first step in approaching the invention of novel methods for treatment. In the present study, we analyzed 15 human pancreatic cancer cell lines for genetic alterations of the K-ras, p53, p16, and SMAD4 genes, which are very frequent targets for mutation in pancreatic cancer; these cell lines are useful resources in cancer research.",

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AU - Ohnishi, Y.

AU - Kijima, H.

AU - Horii, Akira

PY - 2001

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AB - Human pancreatic cancer is one of the most malignant diseases in the world. In order to save patients with pancreatic cancer, it is necessary to develop novel methods for treatment. For such a purpose, a series of well-characterized cancer cell lines are of great help for in vitro studies that are generally the first step in approaching the invention of novel methods for treatment. In the present study, we analyzed 15 human pancreatic cancer cell lines for genetic alterations of the K-ras, p53, p16, and SMAD4 genes, which are very frequent targets for mutation in pancreatic cancer; these cell lines are useful resources in cancer research.

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Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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