Chemerin analog regulates energy metabolism in sheep

Yutaka Suzuki; Sang Houn Song; Katsuyoshi Sato; Kyoung Ha So; Astrid Ardiyanti; Shun Kitayama; Yeon Hee Hong; Sung Dae Lee; Ki Choon Choi; Akihiko Hagino; Kazuo Katoh; Sang Gun Roh

doi:10.1111/j.1740-0929.2011.01002.x

Chemerin analog regulates energy metabolism in sheep

Yutaka Suzuki, Sang Houn Song, Katsuyoshi Sato, Kyoung Ha So, Astrid Ardiyanti, Shun Kitayama, Yeon Hee Hong, Sung Dae Lee, Ki Choon Choi, Akihiko Hagino, Kazuo Katoh, Sang Gun Roh

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Accumulating data suggest a relationship between chemerin and energy metabolism. Our group previously described gene cloning, expression analysis and the regulatory mechanism of chemerin and its own receptor in mice and cattle. The objective of the present study was to investigate the physiological effect of chemerin on endocrine changes and energy metabolism in sheep using a biologically stable chemerin analog. The chemerin analog was intravenously administrated (100 or 500μg/head) to sheep, and plasma insulin and metabolites (glucose, nonesterified fatty acids (NEFA), triglyceride, total cholesterol and high-density lipoprotein (HDL) cholesterol) were analyzed. The chemerin analog dramatically increased the insulin levels, and glucose levels were decreased. NEFA levels were slightly decreased at 20min but then increased gradually from 60 to 180min after analog administration. In addition, injection of the chemerin analog immediately increased triglyceride and total cholesterol but not HDL levels. These results suggested that chemerin analog regulated insulin secretion related to glucose metabolism and the release of triglycerides in sheep in vivo. This study provides new information about endocrine and metabolic changes in response to chemerin in sheep.

Original language	English
Pages (from-to)	263-267
Number of pages	5
Journal	Animal Science Journal
Volume	83
Issue number	3
DOIs	https://doi.org/10.1111/j.1740-0929.2011.01002.x
Publication status	Published - 2012 Mar

Keywords

Chemerin analog
Energy metabolism
Insulin secretion
Sheep
Triglyceride release

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)

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10.1111/j.1740-0929.2011.01002.x

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title = "Chemerin analog regulates energy metabolism in sheep",

abstract = "Accumulating data suggest a relationship between chemerin and energy metabolism. Our group previously described gene cloning, expression analysis and the regulatory mechanism of chemerin and its own receptor in mice and cattle. The objective of the present study was to investigate the physiological effect of chemerin on endocrine changes and energy metabolism in sheep using a biologically stable chemerin analog. The chemerin analog was intravenously administrated (100 or 500μg/head) to sheep, and plasma insulin and metabolites (glucose, nonesterified fatty acids (NEFA), triglyceride, total cholesterol and high-density lipoprotein (HDL) cholesterol) were analyzed. The chemerin analog dramatically increased the insulin levels, and glucose levels were decreased. NEFA levels were slightly decreased at 20min but then increased gradually from 60 to 180min after analog administration. In addition, injection of the chemerin analog immediately increased triglyceride and total cholesterol but not HDL levels. These results suggested that chemerin analog regulated insulin secretion related to glucose metabolism and the release of triglycerides in sheep in vivo. This study provides new information about endocrine and metabolic changes in response to chemerin in sheep.",

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author = "Yutaka Suzuki and Song, {Sang Houn} and Katsuyoshi Sato and So, {Kyoung Ha} and Astrid Ardiyanti and Shun Kitayama and Hong, {Yeon Hee} and Lee, {Sung Dae} and Choi, {Ki Choon} and Akihiko Hagino and Kazuo Katoh and Roh, {Sang Gun}",

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AU - Kitayama, Shun

AU - Hong, Yeon Hee

AU - Lee, Sung Dae

AU - Choi, Ki Choon

AU - Hagino, Akihiko

AU - Katoh, Kazuo

AU - Roh, Sang Gun

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N2 - Accumulating data suggest a relationship between chemerin and energy metabolism. Our group previously described gene cloning, expression analysis and the regulatory mechanism of chemerin and its own receptor in mice and cattle. The objective of the present study was to investigate the physiological effect of chemerin on endocrine changes and energy metabolism in sheep using a biologically stable chemerin analog. The chemerin analog was intravenously administrated (100 or 500μg/head) to sheep, and plasma insulin and metabolites (glucose, nonesterified fatty acids (NEFA), triglyceride, total cholesterol and high-density lipoprotein (HDL) cholesterol) were analyzed. The chemerin analog dramatically increased the insulin levels, and glucose levels were decreased. NEFA levels were slightly decreased at 20min but then increased gradually from 60 to 180min after analog administration. In addition, injection of the chemerin analog immediately increased triglyceride and total cholesterol but not HDL levels. These results suggested that chemerin analog regulated insulin secretion related to glucose metabolism and the release of triglycerides in sheep in vivo. This study provides new information about endocrine and metabolic changes in response to chemerin in sheep.

AB - Accumulating data suggest a relationship between chemerin and energy metabolism. Our group previously described gene cloning, expression analysis and the regulatory mechanism of chemerin and its own receptor in mice and cattle. The objective of the present study was to investigate the physiological effect of chemerin on endocrine changes and energy metabolism in sheep using a biologically stable chemerin analog. The chemerin analog was intravenously administrated (100 or 500μg/head) to sheep, and plasma insulin and metabolites (glucose, nonesterified fatty acids (NEFA), triglyceride, total cholesterol and high-density lipoprotein (HDL) cholesterol) were analyzed. The chemerin analog dramatically increased the insulin levels, and glucose levels were decreased. NEFA levels were slightly decreased at 20min but then increased gradually from 60 to 180min after analog administration. In addition, injection of the chemerin analog immediately increased triglyceride and total cholesterol but not HDL levels. These results suggested that chemerin analog regulated insulin secretion related to glucose metabolism and the release of triglycerides in sheep in vivo. This study provides new information about endocrine and metabolic changes in response to chemerin in sheep.

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KW - Triglyceride release

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Chemerin analog regulates energy metabolism in sheep

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