Chemical and etiological studies on tetrodotoxin and its analogs

Takeshi Yasumoto, Mari Yotsu-Yamashita

Research output: Contribution to journalReview articlepeer-review

86 Citations (Scopus)


The marked fluctuation of tetrodotoxin (TTX) contents in pufferfish led us to suspect the exogenous origin of the toxin. Based on a food chain hypothesis, various marine biota were tested for TTX with a fluorometric tetrodotoxin analyzer. Consequently, bacteria were found to be the genetic origin of TT. The survey also revealed the occurrence of new TTX analogs in pufferfish, newts and a frog. Those analogs were isolated and their chemical structures were determined. The analogs provided valuable information on biosynthetic as well as metabolic pathways of TTX and on structure-activity relationship.

Original languageEnglish
Pages (from-to)81-90
Number of pages10
JournalJournal of Toxicology - Toxin Reviews
Issue number2
Publication statusPublished - 1996


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